Figure 1

Central metabolic and aromatic pathways. The figure shows key metabolites, genes involved in their transformation, and genes coding for carbon transporters for those carbon sources coutilized by strain PB12. In this strain PTS is not functional. PB12 utilizes GalP permease and Glk for glucose transport and phosphorylation, respectively. Therefore, PEP that is not used for this purpose can be canalized for aromatic production [6,7]. Broken lines indicate the usual role and synthesis of some metabolites in the presence of PTS. Abbrevations are: glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), fructose-1,6-phosphate (F1,6P), dihydroxy-acetone-phosphate (DHAP), glyceraldehyde-3-phosphate (GA3P), glyceraldehyde-1,3-phosphate (G1,3P), 3-phosphoglycerate (3PG), 2-phosphoglycerate (2PG), phosphoenolpyruvate (PEP), pyruvate (PYR), acetyl-CoA (AcCoA), acetyl phosphate (Ac-P), acetyl-AMP (Ac-AMP), citrate (CIT), glyoxylate (GOx), α-ketoglutarate (α-KG), succinyl-coenzyme A (SUC-CoA), succinate (SUC), fumarate (FUM), malate (MAL), oxaloacetate (OAA), 6-phosphogluconolactone (6PGNL), 6-phosphogluconate (6PGNT), ribulose-5-phosphate (RU5P), ribose-5-phosphate (R5P), xylulose-5-phosphate (X5P), seudoheptulose-7-phosphate (S7P), erythrose-4-phosphate (E4P), 2-keto-3-deoxy-6-phosphogluconate (KDPGNT), 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP), 3-dehydroquinate (DHQ), 3-dehydroshikimate (DHS), shikimate (SHIK), chorismate (CHO), prephenate (PPA), phenylpyruvate (PPI), L-phenylalanine (Phe), L-tyrosine (Tyr), L-tryptophane (Trp).