Figure 6
From: Hitting bacteria at the heart of the central dogma: sequence-specific inhibition
Hairpin core sequence. Generalized representation of a minimal hairpin-substrate complex. N: any nucleotide, N': nucleotide complementary to N, H: any nucleotide but C, Y: pyrimidine nucleotide. Nucleotides in boldface indicate the conserved catalytic core nucleotides, and the arrow marks the cleavage site. Ribozyme numbering is according to Butcher and Burke [220, 221]. This representation displays in trans cleavage, but the catalytic core nucleotides and the cleavage site are the same for in cis cleavage.