Figure 4
From: Hitting bacteria at the heart of the central dogma: sequence-specific inhibition
Hammerhead core sequence. Generalized representation of a hammerhead-substrate complex. N: any nucleotide, N': nucleotide complementary to N, H: any nucleotide but G, Y: pyrimidine nucleotide, R: purine nucleotide complementary to Y. Nucleotides in boldface indicate the conserved catalytic core nucleotides, and the arrow marks the cleavage site. Ribozyme numbering is according to Hertel et al. [219]. This representation displays in trans cleavage, but the catalytic core nucleotides and the cleavage site are the same for in cis cleavage.