Figure 3
From: Hitting bacteria at the heart of the central dogma: sequence-specific inhibition
External Guide Sequences. A) Representation of precursor tRNA, a natural substrate for E. coli RNase P. The anticodon is shown in red, and the sequences imitated by EGS annealing are highlighted in boldface. B) An EGS molecule annealing to an RNA substrate. C) An EGS molecule with an attached catalytical M1 RNA subunit annealing to an RNA substrate. Arrows mark the RNase P or M1 RNA cleavage sites.