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Table 2 Benefical effects of short chain fatty accids (SCFA)

From: Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease

SCFA Model Effect Reference
Butyrate Tumorigenesis in rat colon and Human colonic cells Inhibit the genotoxic activity of nitrosamides and hydrogen peroxide [47]
Human adenocarcinoma R6/C2 and AA/C1 cells and carcionoma PC/JW/F1 cells Induce apoptosis [48]
Human intestinal primary epithelial cells (HIPEC), HT-29 and Caco-2 cells Immunoregulatory effects [49]
Humans with distal ulcerative colitis Improves UC symthoms [50]
Butyrate/acetate/propionate Humans with diversion colitis Improves the macroscopic and histological signs of inflammation [51]
Propionate HT-29 cells Anti-proliferative effects [52]
Madin-Darby bovine kidney epithelial cells (MDBK) [53]
Acetate E. coli O157:H7 infection Protection [54]