Table 2 Benefical effects of short chain fatty accids (SCFA)
From: Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease
SCFA | Model | Effect | Reference |
|---|---|---|---|
Butyrate | Tumorigenesis in rat colon and Human colonic cells | Inhibit the genotoxic activity of nitrosamides and hydrogen peroxide | [47] |
Human adenocarcinoma R6/C2 and AA/C1 cells and carcionoma PC/JW/F1 cells | Induce apoptosis | [48] | |
Human intestinal primary epithelial cells (HIPEC), HT-29 and Caco-2 cells | Immunoregulatory effects | [49] | |
Humans with distal ulcerative colitis | Improves UC symthoms | [50] | |
Butyrate/acetate/propionate | Humans with diversion colitis | Improves the macroscopic and histological signs of inflammation | [51] |
Propionate | HT-29 cells | Anti-proliferative effects | [52] |
Madin-Darby bovine kidney epithelial cells (MDBK) | [53] | ||
Acetate | E. coli O157:H7 infection | Protection | [54] |