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Figure 1 | Microbial Cell Factories

Figure 1

From: Replicating DNA by cell factories: roles of central carbon metabolism and transcription in the control of DNA replication in microbes, and implications for understanding this process in human cells

Figure 1

The scheme of the central carbon metabolism (CCM, upper panel), with indicated genes coding for enzymes involved in particular reactions. Colored backgrounds indicate glycolysis/gluconeogenesis (green), pentose phosphate pathway (violet), the overflow reactions (gray), and the Krebs cycle (yellow). Lower panel demonstrates the pattern of suppressions of effects of mutations in genes coding for replication factors in B. subtilis and E. coli by particular mutations in genes coding for CCM enzymes, involved in glycolysis/gluconeogenesis, pentose phosphate pathway (PPP) or the overflow reactions. In both panels, red color indicates specific suppressions in B. subtilis, and blue color indicates specific suppressions in E. coli. Abbreviations: 1,3-BGP, 1,3-biphosphoglycerate; 2PG, 2-phosphoglycerate; 3PG, 3-phosphoglycerate; G3P, galactose-3-phosphate; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; OXA, oxaloacetate; PBP, fructose-1,6-biphosphate; GAP, glyceraldehyde 3-phosphate; PEP, phosphoenolpyruvate; PYR, pyruvate; Ru5P, ribulose-5-phosphate; R5P, ribose-5-phosphate; S7P, sedoheptulose-7-phosphate; E4P, erythrose-4-phosphate; Ac-CoA, acetyl coenzyme A; Acetyl-P, acetyl phosphate; Ac-AMP, acetyl-AMP; CIT, citrate; SUC, succinate; X5P, xylulose-5-phosphate.

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Microbial Cell Factories

ISSN: 1475-2859

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