Figure 1
From: Enhanced membrane protein expression by engineering increased intracellular membrane production
Schematic presentation of the major steps in phospholipid biosynthesis in yeast [[6]]. Phosphatidic acid phosphatase, encoded by PAH1, catalyzes the dephosphorylation of PA to DAG, the precursor of the storage lipid TAG (there are 3 more genes coding for enzymes with this activity in yeast, but only PAH1 is involved in the synthesis of TAG and the regulation of phospholipid synthesis [7]). All phospholipids can be derived from PA, with the exception of phosphatidylinositol which needs exogenous inositol input. PA, phosphatidic acid; DAG, diacylglycerol; TAG, triacylglycerol; PI, phosphatidylinositol; CL, cardiolipin; PS, phosphatidyl-serine; PE, phosphatidylethanolamine; PC, phosphatidylcholine.