Figure 1
From: Packaging protein drugs as bacterial inclusion bodies for therapeutic applications
A. 40-Section confocal xyz stack of HeLa cells exposed to GFP IBs, showing IB cell penetrability. Cell membrane is labeled in red and the nuclear material is seen in blue. IBs are observed under their natural green fluorescence as discrete particulate entities. B. GFP IBs embedded or crossing the nuclear membrane are shown in two stack versions, in which the cell membrane is either shown (left) or hidden (right) for clarity. Modified from reference[25] (Copyright Wiley-VCH Verlag GmbH & Co, KGaA. Reproduced with permission).