Figure 1

Amino acid sequence of lunasin and activity of regions of the peptide. Lunasin is a 43-amino acid peptide consisting of four regions. The function of residues 1-22 is currently unknown. Residues 23-31 target lunasin to chromatin. The Arg-Gly-Asp cell recognition sequence of residues 32-34 is known to internalise lunasin into the cell nucleus. The poly-aspartyl end of lunasin (residues 35-43) is responsible for binding it to the core histones within the chromatin. Adapted from [4].