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Figure 2 | Microbial Cell Factories

Figure 2

From: Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome

Figure 2

Occurrence of entotoxemia upon high fat diet feeding and obesity. An increase level of lipopolysaccharides (LPS) characterizes obese and diabetic individuals. This effect is mostly due to processes involving the transport of LPS from the gut to the blood, those processes being an increase in chylomicron-driven transport of LPS, a rupture of the gut barrier integrity leading to abnormal gut permeability, and a decrease in processes involved in intestinal LPS degradation (alkaline phosphatase activity). The increase in LPS (endotoxemia) thereby activates the macrophages in the different tissues leading to a low tone inflammation involved in the metabolic alterations occurring upon obesity.

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Microbial Cell Factories

ISSN: 1475-2859

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