Figure 5

A schematic view on the inter-connection of cellular responses during growth on low phosphate levels. All labeled genes (left hand side) and illustrated proteins (right hand side) showed significantly up-regulated transcript levels when cells were grown under low phosphate levels [9.6 mM]. The up-regulated pathways included the glycerol biosynthesis (orange background), the lower part of glucose fermentation, being significantly increased downstream from the pyruvate decarboxylation step (blue background), the phosphatidylinositol biosynthesis and the lower part of inositol phosphate biosynthesis pathways (green background), yielding in heptakisphosphate (IP₇) which has been shown to regulate the inhibitory activity of Pho81, thus allowing the transcription factor Pho4 to access the nucleus and induce the PHO pathway. Metabolites: Glc glucose, G6P glucose-6-phosphate, F1, 2 bP fructose-1,2-bisphosphate, DHAP dihydroxyacetone, Gro-3-P glycerol-3-phosphate, GAP glyceraldehyde-3-phosphate, AcAld acetaldehyde, Ino-3-P inositol-3-phosphate, PI phosphatidylinositol, IP₃ inositol triphosphate, IP₇ inositol heptakisphosphate, GroPIns glycerophosphoinositol, LPA lyso-phosphatidic acid.