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Fig. 8 | Microbial Cell Factories

Fig. 8

From: Deciphering antifungal and antibiofilm mechanisms of isobavachalcone against Cryptococcus neoformans through RNA-seq and functional analyses

Fig. 8

(A) Detailed diagram of molecular docking between IBC and target proteins, including KRE6, SKN1, ERG11, AFR1, MCA1, DNM1, HOB1 and GAT201. The 2D and 3D intermolecular contact between IBC and target proteins. Chemical structures were drawn by ChemDraw Pro 16.0 Suite (PerkinElmer, USA) and analyzed by the Discovery studio visualizer. IBC was represented in light blue, and local magnification of the docking sites and 2D diagram of the interactions were shown. (B) RT-qPCR assay for representative DEGs to validate the result of functional enrichment analysis. Data in the bar graphs are presented as the means and standard deviations of three independent experiments. (C) Effect of IBC on the lifespan of C. neoformans-infected C. elegans nematodes was evaluated, and the survival curve was plotted. Survival of C. elegans was evaluated in different treatment groups. Values represented the mean survival rates of three biological replicates

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Microbial Cell Factories

ISSN: 1475-2859

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