Table 1 Stoichiometric and kinetic growth parameters of E. coli BL21 (DE3) producer of RBD-P and RBD growing in shake flasks and bioreactor

0.45 ± 0.01^a

0.49 ± 0.01^b

0.41 ± 0.03^c

0.42 ± 0.01^c

5.81 ± 0.25^a

5.56 ± 0.39^a

13.90 ± 2.73^b

14.91 ± 1.46^b

7.3 ± 0.2^a

6.7 ± 0.1^b

14.2 ± 1.7^c

13.8 ± 0.2^d

0.21 ± 0.02^a

0.20 ± 0.01^a

0.26 ± 0.01^b

0.24 ± 0.02^b

0.066 ± 0.028^a

0.087 ± 0.027^a

0.113 ± 0.014^b

0.169 ± 0.034^c

1.088 ± 0.112^a

1.039 ± 0.092^a

0.871 ± 0.288^b

1.651 ± 0.371^c

1.154 ± 0.132^a

1.126 ± 0.116^a

0.930 ± 0.323^b

1.819 ± 0.413^c

0.28 ± 0.01^a

0.26 ± 0.02^a

0.33 ± 0.01^b

0.46 ± 0.01^c

24 ± 4^a

23 ± 5^a

35 ± 5^b

25 ± 4^a

0.14 ± 0.02^a

0.13 ± 0.02^a

0.07 ± 0.02^b

0.09 ± 0.01^b