Fig. 9

Integrative correlation network between intestinal mucosal microbiota and targeted amino acid metabolism. Low part: Network of intestinal mucosal microbiota and serum amino acid metabolism in mice based on the Pearson correlation between all samples. Mid part: Network of intestinal mucosal microbiota and serum amino acid metabolism in mice, based on the Pearson correlation of groups in the normal control group (i.e., Healthy mice) and the cold and humid environmental stress treatment group (i.e., Intestinal mucus barrier injury mice), respectively. Up part: Microbiota Co-occurrence network, based on microbiota species abundance and the Pearson correlation of groups in the normal control group (i.e., Healthy mice) and the cold and humid environmental stress treatment group (i.e., Intestinal mucus barrier injury mice), respectively. The integrative correlation network is based on microbiota species abundance, metabonomic amino acid quantification and Pearson correlation in all samples (R ≥ 0.7, FDR < 0.06). Red, grey, and green circled shapes are related to the amino acid, microbiota species, and Lactobacillus reuteri, respectively; and yellow circled shapes in microbiota Co-occurrence network represent the significance differential microbiota between cold and humid environmental stressed mice and normal control mice (Wilcoxon signed-rank test, FDR < 0.05). The green and red edges represent positive and negative correlations, respectively (R ≥ 0.7, FDR < 0.05); and the grey edges represent a hint of significance (R ≥ 0.7, 0.05 ≤ FDR < 0.06). The width of the edge represents the correlation coefficient; the greater the width, the stronger the correlation