Three new LmbU targets outside lmb cluster inhibit lincomycin biosynthesis in Streptomyces lincolnensis

Table 2 Candidate target genes of LmbU

Genes	Products	Putative function	Position of putative LmbU site to TRSS^a
*SLINC_0469*	WP_067426176.1, 988 aa	LAL family transcriptional regulator	−316 – −307
*SLINC_1037*	WP_079164420.1, 635 aa	AcoR family transcriptional regulator	−281 – −272
SLINC_4499	WP_067445653.1, 186 aa	TetR family transcriptional regulator	+89 – +98
*SLINC_8097*	WP_067443797.1, 301 aa	AraC family transcriptional regulator	−365 – −356
*SLINC_0585*	WP_067426389.1, 510 aa	MFS transporter	−172 – −163
SLINC_1746	WP_067429133.1, 275 aa	ABC transporter substrate-binding protein	−176 – −167
*SLINC_6382*	WP_067441376.1, 327 aa	ABC transporter permease	−428 – −419
SLINC_RS37445	WP_067446118.1, 135 aa	vicinal oxygen chelate family protein	−322 – −313
*SLINC_7298*	WP_067443078.1, 478 aa	MFS transporter	−346 – −337
SLINC_6232	WP_067445952.1, 511 aa	RNA polymerase sigma factor	−549 – −540
*SLINC_6570*	WP_067441886.1, 201 aa	RNA polymerase sigma factor	−549 – −540
*SLINC_1077*	WP_067427571.1, 256 aa	methyltransferase	−492 – −483
SLINC_4366	WP_067436406.1, 574 aa	methionine–tRNA ligase	−215 – −206
SLINC_6271	WP_067441084.1, 194 aa	PaaI family thioesterase	−281 – −272

ISSN: 1475-2859