Fig. 1
From: Methanol bioconversion into C3, C4, and C5 platform chemicals by the yeast Ogataea polymorpha
Metabolic modifications introduced into O. polymorpha for producing malate, acetone, or isoprene from methanol as carbon source. Used abbreviations: Pyc(P): pyruvate carboxylase, OAA: oxaloacetate Mdh(p): malate dehydrogenase, Mae1(p): malic acid transporter, ThlA(p): acetyl-CoA acetyltransferase, AcetoACoA: acetoacetyl-CoA, CtfAB(p): butyrate-acetoacetate CoA-transferase, YbgC(p): thioesterase, Adc(p): acetoacetate decarboxylase, tHmgr(p): truncated 3-hydroxy-3-methylglutaryl-CoA reductase, Isps(p): isoprene synthase, HMG-CoA: 3-hydroxy-3-methylglutaryl coenzyme A, DMAPP: dimethylallyl pyrophosphate