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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Systematic engineering enables efficient biosynthesis of L-phenylalanine in E. coli from inexpensive aromatic precursors

Fig. 1

Design the artificial biosynthetic pathways for L-phenylalanine production from aromatic precursors (benzaldehyde or benzyl alcohol) and glycine. Gray arrows indicated the natural biosynthesis pathway of L-phenylalanine in E. coli. The green and red arrows demonstrated the novel pathway. ADH alcohol dehydrogenase, LTA threonine aldolase, LTD threonine dehydratase, PheDH phenylalanine dehydrogenase, FDH formate dehydrogenase. The dotted gray arrows indicate the repression and inhibition of the relevant genes in native pathway. Metabolites abbreviations: G6P glucose 6-phosphate, DAHP 3-deoxy-d-arabino- heptulosonate-7-phosphate, L-Glu L-glutamate, 2-KG 2-ketoglutarate

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Microbial Cell Factories

ISSN: 1475-2859

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