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Table 7 The best solutions based on the desired evaluation indexes for succinate production under anaerobic condition (Strain0 in CM2 cultivation medium) in iJR904

From: FastKnock: an efficient next-generation approach to identify all knockout strategies for strain optimization

Number of Knocked out reaction

Evaluation index

SSP (h−1)

(FBA-based calculations)

SSP (h−1)

(LinearMoMA-based calculations) [62])

SoGC (h−1)

(FBA-based calculations)

Best knockout strategy

Biomass formation rate (h−1)

Succinate production rate (mmol g DW−1)

SSP (h−1) × 10

Best knockout strategy

Biomass formation rate (h−1)

Succinate production rate (mmol g DW−1)

SSP (h−1) × 10

Best knockout strategy

Biomass formation rate (h−1)

Succinate production rate (mmol g DW−1)

SSP (h−1) × 10

1

ADHEr

0.16

0.83

0.14

ADHEr

0.03

2.38

0.08

ADHEr

0.03

2.38

1.34

2

ADHEr, LDH_D

0.16

8.73

1.43

ADHEr, ATPS4r

0.12

8.32

1.01

ADHEr, LDH_D

0.16

8.73

1.35

3

ADHEr, LDH_D, PFL

0.12

12.24

1.53

ADHEr, ATPS4r, RPE

0.13

8.60

1.19

ADHEr, ATPS4r, LDH_D

0.16

8.90

3.01

4

ADHEr, LDH_D, PFL, URIK2

0.12

12.24

1.53

ADHEr, ATPS4r, LDH_D, RPE

0.13

8.71

1.20

ADHEr, LDH_D, HEX1, THD2

0.13

9.88

3.09

5

ADHEr, P, PFL, SUCOAS, RNDR3

0.12

12.25

1.54

ADHEr, ATPS4r, GLYK, F6PA, RPE

0.14

8.63

1.23

ADHEr, LDH_D, HEX1, THD2, DRPA

0.13

9.87

3.10