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Fig. 2 | Microbial Cell Factories

Fig. 2

From: From waste to health-supporting molecules: biosynthesis of natural products from lignin-, plastic- and seaweed-based monomers using metabolically engineered Streptomyces lividans

Fig. 2

Genetic cluster architecture for the synthesis of bottromycin (A) and pamamycin (B) in recombinant S. lividans ΔYA8. The heterologous host S. lividans ΔYA8-DG2 contains a genomic copy of the 18 kb bottromycin biosynthesis-related cluster from Streptomyces sp. BC16019 [20]. The cluster is expressed under the control of synthetic P41 promoters, whereby hygR displays a resistance marker introduced during the cloning process. The heterologous host S. lividans ΔYA8-R2 contains a genomic copy of the 25 kb pamamycin biosynthesis-related cluster from Streptomyces alboniger DSMZ 40043 [38]. The cluster is expressed under the control of native promoters

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Microbial Cell Factories

ISSN: 1475-2859

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