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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Improved production of Taxol® precursors in S. cerevisiae using combinatorial in silico design and metabolic engineering

Fig. 1

A The native biochemical reactions in the mevalonate pathway leading to the production of GGPP in yeast. B The Taxol® biosynthesis from GGPP in yew trees. HMG-CoA: hydroxymethylglutaryl-CoA, mevalonate-P: R-5-hosphomevalonate, mevalonate-PP: R-5 diphosphomevalonate, IPP: isopentenyl diphosphate, DMAPP: dimethylallyl diphosphate, GPP: geranyl diphosphate, FPP: farnesyl diphosphate, GGPP: geranylgeranyl diphosphate, T5α-ol: taxa-4(20),11-dien-5α-ol, T5αAc: taxa-4(20),11-dien-5-α-yl acetate. The dashed arrows represent naturally occurring multiple steps

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Microbial Cell Factories

ISSN: 1475-2859

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