From: Induction of the CtsR regulon improves Xylanase production in Bacillus subtilis
FC 3Â h | FC 6Â h | Gene(s) | Operon | Regulon | Function |
---|---|---|---|---|---|
2800 | 3400 | xynA | Â | Â | Endo-1,4-beta-xylanase |
5.6/3 | 1.4/− 1.0 | yxeK,N,M,O,Q,snaB, sndB | yxeK (7) | CymR 100%↓ | Uptake, utilization, detoxification S-(2-succino) cysteine |
5.2 | 1.1 | yvdE | yvdE (9) | Â | Unknown |
3.9 | 1.4 | sndA | snaA (12) | CymR 100%↓ | Utilization of S-methyl-cysteine |
3.9/3 | 1.4/− 1.1 | cysH,P,C,sat,ylnD | cysH (7) | CymR 100%↓ | Sulfate uptake & reduction |
3.1/2.3 | 1.2/− 1.4 | pyrAA,AB,D,E,F,K | pyrR (10) | PyrR 0%-80% | Pyrimidine biosynthesis |
3.0 | 1.5 | yeeG | Â | Â | Unknown |
3.0 | 1.1 | tcyP |  | CymR 100%↓ | Cystine (cysteine dimer) uptake |
2.7 | 1.4 | spoVID | spoVID (2) | SigE 96%↑ | Spore coat assembly |
2.6 | 1.8 | dppB | dppA (5) | CodY 91%↓ | Dipeptide transporter subunit |
3 | 1.3 | nupO | nupN (4) | CodY 91%↓ | Uptake of guanosine |
3 |  − 1.1 | putB | putB (3) | PutR 100%↑ | Proline dehydrogenase |
2.1 | 1.1 | rhiL | rhiL (4) | Â | Uptake of rhamnose oligosaccharides |
2.0 | 2.1 | leuB | ilvB (7) | CcpA 87%↑ | Biosynthesis of leucine |
 − 4.4 |  − 8.2 | melR | melR (5) | MelR 100%↑ | repressor melibiose utilization operon |
 − 3.9 |  − 13.4 | clpE |  | CtsR 100%↑ | AAA unfoldase |
 − 3.0 |  − 2.0 | iseA |  | WalR 100%↑ | Inhibitor of autolysins |
 − 3.0/− 3 |  − 1.7/− 1.2 | rbsA,B,C,D,K,R | rbsR (6) | CcpA 87%↑ | Ribose uptake |
 − 3.0/− 2.4 |  − 1.4 | yyzE,bglA | bglA (2) |  | Beta-glucoside utilization |
 − 3.0/− 2.3 |  − 1.7/− 1.4 | licA,B,C,H | licB (4) | LicR 100%↓ | Lichenan uptake and phosphorylation |
 − 2.8/− 2.1 |  − 1.4/− 1.2 | araA,B,D,L,M,N,abfA | araA (9) | AraR 100%↑ | Arabinose utilization |
 − 2.8 |  − 1.1 | glpD |  | GlpP 100%↓ | Glycerol-3-phosphate dehydrogenase |
 − 3 |  − 1.6 | ywsB |  | SigB 100%↓ | General stress protein |
 − 2.4/− 2.1 | 1.5/1.3 | khtT,U,S | khtS (3) |  | Potassium ion efflux |
 − 2.3/− 2.1 |  − 1.5/− 1.3 | gntK,R | gntR (4) | GntR 100%↑ | Gluconate utilization |
 − 2.3 | 1.4 | mrgA | yusZ (2) | PerR 100%↑ | Protecting against oxidative killing |
 − 2.3 |  − 1.2 | ylbP |  |  | Unknown |
 − 2.3 |  − 2.7 | yerA | yerA (3) | CcpA 87%↑ | Similar to adenine desaminase |
 − 2.2/− 2.0 |  − 2.6/− 2.0 | ctsR, mcsA,B,clpC | ctsR (6) | CtsR 100%↑ | Class iii heat shock proteins |
 − 2.2 |  − 1.8 | yuaF | yuaF (3) | SigW 100%↓ | Involved membrane fluidity control |
 − 2.1 | 1.3 | manR |  | ManR 100%↓ | Regulation of mannose utilization |
 − 2.1/− 2.0 |  − 1.7/− 1.4 | ganA,P,S | ganS (5) | GanR 100%↑ | Uptake of galactotriose |
 − 2.1 |  − 1.1 | trpB | trpE (6) | MtrB 0%-13% | Tryptophan synthase subunit |
 − 2.1 | 1.1 | katA |  | PerR 100%↑ | Main catalase |
 − 2.0 |  − 1.4 | gmuB | gmuB (8) | GmuR 100%↑ | Glucomannan utilization |
 − 2.0 |  − 1.0 | uxaC | uxaC (10) | CcpA 87%↑ | Glucuronate isomerase |