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Fig. 2 | Microbial Cell Factories

Fig. 2

From: Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites

Fig. 2

Endophyte mediated enhanced production of secondary metabolites and its applications. A Depicts plants inoculated with beneficial endophytes, significantly improving plant growth and development over non-inoculated plants. The zoomed-out leaf portion represents the modulation of host plant secondary metabolic pathways by multiple transcription factors regulated by upstream signals in response to endophytic colonization. B Different categories of bioactive secondary metabolites (structures given alongside) and their multifaceted industrial applications. microbe-associated molecular patterns (MAMPs), transcription factors (TFs), secondary metabolite (SM), mevalonic acid (MVA), methylerythritol phosphate (MEP), acetoacetyl CoA thiolase (AACT), 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), mevalonate kinase (MVK), phosphor mevalonate kinase (PMK), -hydroxy-3-methylglutary-CoA (HMG-CoA), 3 mevalonate5-diphosphate decarboxylase (MVD), isopentenyl diphosphate (IPP), dimethylallyl diphosphate (DMAPP), IPP isomerase (IDI), mevalonate pyrophosphate (MVPP), farnesyl-diphosphate synthase (FPS), famesyldiphosphate (FPP), geranyl phosphate synthase (GPS), geranyldiphosphate (GPP), geranyl diphosphate synthase (GPPS), geranyl geranyl diphosphate (GGPP), geranyl geranyl diphosphate synthase (GGPPS), 1-deoxy-D-xylulose5-phosphate synthase (DXS), 1-deoxy-D-xylulose5-phosphate (DXP), 1-deoxy-D-xylulose5-phosphate reductoisomerase (DXR), MEP cytidylyltransferase (MCT), 1-hydroxy-2-methyl-2-(E)-butenyl4-diphosphate synthase (HDS), MEP-cPP synthase (MCS), squalene synthase (SQS), cytochrome P450 reductase (CPR), sterol methyltransferase (SMT), squalene epoxidase (SQE)

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