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Table 1 MIC of pamamycin 607 for different S. albus J1074 strains

From: Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster

Strain

MIC, μg/mL

S. albus J1074 pUWLH

0.78

S. albus J1074 pUWLHpamS

1.56

S. albus J1074 pUWLHpamW

3.12

S. albus J1074 R2

12.5

  1. MIC minimal inhibitory concentration, R2 cosmid carrying the pam BGC, pUWLH replicative expression vector, pamS putative pamamycin hydrolase; pamW, putative pamamycin exporter
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Microbial Cell Factories

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