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Table 2 Expression of genes associated with CoA thioester metabolism

From: Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer

Locus tag

Annotation

HP126

HP126 Δv3

SRIMR7_19995

BC α-keto acid dehydrogenase E1 subunit α

5.0

−2.9

SRIMR7_20005

BC α-keto acid dehydrogenase E2

4.7

−2.7

SRIMR7_20000

BC α-keto acid dehydrogenase E1 subunit β

4.6

−2.7

SRIMR7_19935

1,2-Phenylacetyl-CoA epoxidase, subunit E

4.1

−1.4

SRIMR7_19940

1,2-Phenylacetyl-CoA epoxidase, subunit D

3.5

−1.0

SRIMR7_19945

1,2-Phenylacetyl-CoA epoxidase, subunit C

3.3

0

SRIMR7_35410

Phenylacetate-CoA ligase

3.1

−1.3

SRIMR7_34430

Coenzyme A biosynthesis protein CoaBC

2.9

0

SRIMR7_11535

Putative propionyl-CoA carboxylase β-chain

1.1

−2.6

SRIMR7_11575

BC amino-acid aminotransferase

1.0

−1.0

SRIMR7_01685

Crotonyl-CoA carboxylase/reductase

−6.4

0

SRIMR7_07230

Methylmalonyl-CoA mutase

−2.5

2.5

SRIMR7_07225

Crotonyl-CoA carboxylase/reductase

−2.4

2.4

SRIMR7_21110

Valine dehydrogenase

−1.7

0

SRIMR7_02335

3-Hydroxybutyryl-CoA dehydrogenase

−1.9

0

SRIMR7_12355

Methylmalonyl-CoA mutase

−1.2

−1.4

SRIMR7_33660

3-Hydroxybutyryl-CoA dehydrogenase

−1.2

1.2

  1. The data are taken from the transcriptome analysis of S. rimosus ATCC 10970 and its mutagenized derivative HP126 (Fig. 2), which were sampled during the major production phase (24 h). The reference for S. rimosus HP126 was S. rimosus ATCC 10970, while the reference for S. rimosus HP126 Δv3 was S. rimosus HP126. n = 3