Fig. 5

Transcriptomic and proteomic profiling of the wild type S. rimosus ATCC 10970 (R7), its mutagenized oxytetracycline-producing derivative HP126 (HP), and the chassis strain HP126 ∆v3 (DV3), created by deletion of the oxytetracycline cluster. The data show differences in the expression of genes associated with primary catabolic and anabolic carbon metabolism (A) and secondary metabolism (B). The differences in expression are represented as M-values between strain HP versus R7 (y-axis) and strain DV3 versus wild-type (x-axis) so that correlations between all strains can be inferred from the plot. The data represent the major phase of oxytetracycline production after 24 h. The functional annotation of genes, designated by SRIMR7 numbers on basis of the sequenced genomes, is provided in Additional file 2. Correlation between gene expression and protein abundance in all strains after 24 h (C). The differences between strains are represented as M-values for the proteome (y-axis) and the transcriptome (x-axis). The oxytetracycline cluster genes are shown in orange (HP versus R7) and dark blue (DV3 versus R7). n = 3