Fig. 2

Growth and oxytetracycline production in wild-type S. rimosus ATCC 10970 (R7) and its hyperproducing mutagenized derivative HP126. The data comprise the fermentation profiles over time on mannitol-based minimal medium (A, B) and the resulting specific oxytetracycline production rate (C, D). The phases of (i) exponential growth without oxytetracycline production, (ii) reduced growth and production at the onset of phosphate limitation, and (iii) major oxytetracycline production during the stationary phase are indicated by vertical lines. n = 3