Table 4 The effects of signal peptide hydrophobicity on the secretion of mAb1 and mAb2 heavy chain
From: Enhancing full-length antibody production by signal peptide engineering
Signal peptide | Cargo protein | Mature HCÂ % |
|---|---|---|
ssSTII1 | mAb1HC | 35 |
ssSTII1 S-13L | mAb1HC | 79 |
ssDsbA1 | mAb1HC | 86 |
ssDsbA1 L-9S | mAb1HC | 13 |
ssSTII1 | mAb2HC | 17 |
ssSTII1 S-13L | mAb2HC | 78 |
ssDsbA1 | mAb2HC | 89 |
ssDsbA1 L-9S | mAb2HC | 72 |