Growth-rate dependency of de novo resveratrol production in chemostat cultures of an engineered Saccharomyces cerevisiae strain

Table 2 Physiological characteristics of FS09322 and congenic strain CEN.PK113-7D in aerobic glucose-limited chemostats

	FS09322	CEN.PK113-7D
Concentrations (µM)
Resveratrol	437 ± 39	nd
Coumaric acid	86 ± 11	nd
Phloretic acid	120 ± 20	nd
Cinnamic acid	20 ± 10	nd
Biomass specific uptake and production rates (mmol g ⁻¹_X h ⁻¹)
Glucose	−1.22 ± 0.03	−1.11 ± 0.01
CO₂	3.18 ± 0.05	2.65 ± 0.05
O₂	−3.09 ± 0.03	−2.61 ± 0.02
Pooled products	0.02 ± 0.00	nd
Yields on glucose
Biomass (g g⁻¹)	0.44 ± 0.00	0.50 ± 0.00
Resveratrol (mol mol⁻¹)	0.011 ± 0.001
Pooled products (mol mol⁻¹)	0.016 ± 0.002

A dilution rate of 0.10 h⁻¹ was applied. Data represent the average ± standard deviation of measurements on three independent chemostats for resveratrol producing strain FS09322 and two independent chemostats for congenic reference strain CEN.PK113-7D
nd Not detected

ISSN: 1475-2859