Fig. 4From: De novo production of six key grape aroma monoterpenes by a geraniol synthase-engineered S. cerevisiae wine strainSchematic representation of the isoprenoid pathway in S. cerevisiae including the branch point to monoterpenes. Gene names of S. cerevisiae appear in blue. Red and green arrows indicate engineered steps to increase monoterpene content in wines (this work and [17], respectively) catalysed by plant linalool (LIS) and O. basilicum geraniol (GES) synthases. Monoterpene bioconversions appear with red letters [18–20, 28]. HMG-CoA, 3-hydroxy-3-methylglutaryl-coenzyme A; IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl pyrophosphate; GPP, geranyl pyrophosphate; FPP, farnesyl pyrophosphate; GGPP, geranyl geranylpyrophosphate.Back to article page