Table 1 Eukaryotic membrane proteins with high resolution structures.

TRANSMEMBRANE PROTEINS: BETA-BARREL

Beta-Barrel Membrane Proteins: Mitochondrial Outer Membrane

Human VDAC-1 voltage dependent anion channel

E. coli

2K4T¹, 2JK4²

4

[210, 211]

Murine VDAC-1 voltage dependent anion channel

E. coli

3EMN

2.3

[212]

TRANSMEMBRANE PROTEINS: ALPHA-HELICAL

G Protein-Coupled Receptors

Rhodopsin: Bovine Rod Outer Segment mutant N2C/D282C

COS cells

2J4Y

3.4

[122]

Engineered turkey β₁ adrenergic receptor

Trichoplusia ni

2VT4

2.7

[1]

Human β₂ adrenergic receptor, from β₂AR365-Fab5 (2R4R) and β₂AR24/365- Fab5 complexes (2R4S)

Spodoptera frugiperda

2R4R, 2R4S

3.4/3.7

[2]

Engineered human β₂ adrenergic receptor

Spodoptera frugiperda

2RH1, 3D4S

2.4/2.8

[3, 4]

Human A_2A adenosine receptor, In complex with a high-affinity subtype-selective antagonist ZM241385.

Spodoptera frugiperda

3EML

2.6

[5]

Integrin Adhesion Receptors

Human Integrin αIIbβ3 transmembrane-cytoplasmic heterodimer, NMR Structure

E. coli

2KNC

[213]

Snare Protein Family

Syntaxin 1A/SNAP-25/Synaptobrevin-2 Complex from Rattus rattus

E. coli

3HD7

3.4

[214]

Ion Channels

Kir3.1-Prokaryotic Kir Chimera: Mus musculus & Burkholderia xenovorans

E. coli

2QKS

2.2

[7]

ASIC1 Acid-Sensing Ion Channel: Gallus gallus; 2QTS: N- and C-terminal deletions, 3HGC: minimal functional channel

Spodoptera frugiperda

2QTS, 3HGC

1.9/3.0

[8, 215]

ATP-gated P2X4 ion channel (apo protein): Danio rerio (zebra fish) (expressed in SF9 cells), 3.1 Å; Closed state. A construct, 3.5 Å: 3I5D

Spodoptera frugiperda

3H9V, 3I5D

3.1/3.5

[216]

Kv1.2 Voltage-gated potassium Channel: Rattus norvegicus

Pichia pastoris

2A79

2.9

[9]

Kv1.2/Kv2.1 Voltage-gated potassium channel chimera: Rattus norvegicus

Pichia pastoris

2R9R

2.4

[10]

Other Channels: Aquaporins and Glyceroporins

Rat AQP4 aquaporin water channel, S180D mutant (2ZZ9)

Spodoptera frugiperda

2D57, 2ZZ9

3.2/2.8

[11, 12]

Human AQP4 aquaporin water channel

Pichia pastoris

3GD8

1.8

[13]

Human AQP5 aquaporin water channel

Pichia pastoris

3D9S

2.0

[14]

Plant SoPIP2;1 aquaporin: Spinacia oleracea in closed (1Z98) and open conformation (2B5F)

Pichia pastoris

1Z98, 2B5F

2.1/3.9

[15]

Pichia pastoris AQY1 aquaporin, pH 3.5 (2W2E) and 8.0 (2W1P)

Pichia pastoris

2W2E, 2W1P

1.15/1.40

[16]

Other Channels: Gap Junctions

Human Connexin 26 (Cx26; GJB2) gap junction

Spodoptera frugiperda

2ZW3

3.5

[217]

Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism

Human Microsomal Prostaglandin E Synthase 1: Human (Electron Diffraction) In complex with glutathione.

E. coli

3DWW

3.5

[218]

Human 5-Lipoxygenase-Activating Protein (FLAP) with Bound MK-591 Inhibitor (2Q7M), FLAP with iodinated MK-591 analog (2Q7R)

E. coli

2Q7M, 2Q7R

4.0

[219]

Human Leukotriene LTC₄ Synthase in complex with glutathione

S. pombe

2PNO

3.3

[220]

Human Leukotriene LTC₄ Synthase in complex with glutathione/apo form

Pichia pastoris

2UUH, 2UUI

2.15/2.0

[67]

ATP Binding Cassette Transporters

Mus musculus P-Glycoprotein (3G5U), With bound QZ59-RRR (3G60) and QZ59-SSS (3G61)

Pichia pastoris

3G5U, 3G60, 3G61

3.8/4.4/4.35

[6]

P-type ATPase

Human Na,K-ATPase Regulatory Protein FXYD1

E. coli

2JO1¹

[221]

Phospholamban homopentamer: Human sarcoplasmic reticulum

E. coli

1ZLL¹, 1FJK¹, 1FJP¹

[222]

Plasma Membrane H⁺-ATPase: Arabidopsis thaliana

S. cerevisiae

3B8C

3.6

[223]