Source | Mutation | Remarks | References |
---|---|---|---|
Enzymatic proteins | |||
Phosphoglycerate mutase 1 (EC 5.4.2.1) | |||
E. coli | Glu327 | Lower Vmax | 26 |
S. cerevisiae | Gly13Ser | 2-fold increase in activity | 27 |
S. cerevisiae | His181Ala | 11-fold increase in the Km | 28 |
S. cerevisiae | C-terminal 7 res. Deletion | Loss of activity, retention of ligand binding | 29 |
B. stearothermophilus | S62A | Loss of activity, retention of ligand binding | 30 |
S. pombe | H163Q | Reduced mutase and phosphatase activities | 31 |
E. coli | R257A | 11-fold increase in Vmax | 26 |
E. coli | R307A | 700-fold decrease in Vmax | 26 |
Enolase (EC 4.2.1.11) | |||
S. cerrevisiae | S39A | Loss of over 90% activity | 32 |
S. cerrevisiae | H157A, H159A | Loss of over 90% activity | 33 |
S. cerrevisiae | H159A | Loss of over 98% activity | 34 |
Escherichia coli | N341D | Loss of catalytic activity | 35 |
S. cerrevisiae | Gcr1-1 mutation | 20-fold reduction in activity | 36 |
Phosphoglycerate kinase, (EC 2.7.2.3) | |||
S. cerrevisiae | H388G | Reduced kcat and Km | 37 |
S. cerrevisiae | R168K | Increase in Km | 38 |
S. cerrevisiae | R168M | Increase in Km | 38 |
S. cerrevisiae | H62D | Increase in Km and Vmax | 39 |
S. cerrevisiae | D372N | reduction in Vmax by 10-folds | 40 |
S. cerrevisiae | R38A | Complete loss of activity | 41 |
S. cerrevisiae | R38Q | Complete loss of activity | 41 |
S. cerrevisiae | R65Q | Increase in Kd, decrease in Km | 42 |
S. cerrevisiae | R65A | Increase in Kd, decrease in Km | 42 |
S. cerrevisiae | R65S | Increase in Kd, decrease in Km | 42 |
S. cerrevisiae | F194W (and F194L) | decrease in Km, Vmax | 43 |
S. cerrevisiae | R203P | Reduction in kcat | 44 |
Bisphosphoglycerate mutase (EC 5.4.2.4) | |||
S. cerevisiae | H181A | Decrease in kcat | 28 |
Transketolase | |||
S. cerevisiae | E418Q, E418A | 98–99% reduction in activity | 45 |
S. cerevisiae | E418A | E418 is essential for catalytic activity | 45 |
S. cerevisiae | H103A, H103N and H103F | 95–99.9% reduced activity | 46 |
S. cerevisiae | E162A (G) | Impaired catalytic activity and binding | 47 |
S. cerevisiae | D382N(A) | Impaired catalytic activity and binding | 47 |
S. cerevisiae | H481A/S/G | 98.5% reduced specific activity | 48 |
S. cerevisiae | N477A | 1000-fold decrease in kcat/Km | 49 |
S. cerevisiae | H263A | Reduced activity | 50 |
D-3-phosphoglycerate dehydrogenase 2 (EC 1.1.1.95) | |||
Escherichia coli | L-Serine | Reduced activity | 51 |
Triosephosphate isomerase | |||
Kluyveromyces lactis | Kltpi1 mutant | Loss of activity | 52 |
Plasmodium falciparum | Y74G | Reduced stability | 53 |
Plasmodium falciparum | C13D | 7-fold reduction in activity | 54 |
Trypanosoma brucei | W12F | Reduced stability | 55 |
Leishmania mexicana | E65Q | Increased stability | 56 |
K. lactis | DeltaTPI1 mutants | Complete loss of activity | 57 |
Vibrio marinus | A238S mutant | Reduced activity | 58 |
Trypanosoma brucei | C14L | Reduced stability and altered kinetics | 59 |
Saccharomyces cerevisiae | K12R | Vmax reduced by factor of 180 | 60 |
Saccharomyces cerevisiae | K12H | No catalytic activity at neutral pH | 60 |
Saccharomyces cerevisiae | E165D | 100-fold loss in catalytic activity | 61 |
Salmonella typhimurium | R179L | Reduction in binding affinity | 62 |
Trypanosoma brucei | H47N | Reduced stability | 63 |
Escherechia coli | E165D | 100-fold reduction in specific activity | 64 |
Escherechia coli | N78D | Lower kcat | 65 |
Saccharomyces cerevisiae | H95G | 400-fold decrease in catalytic activity | 66 |
Non-enzymatic proteins | |||
Phosphoglycerate transporter protein | |||
Salmonella typhimurium | Â | Â | 67 |
Salmonella typhimurium | Â | Â | 68 |
Bacillus cereus | Â | Â | 69 |
Bacillus anthracis | Â | Â | 70 |
Salmonella typhi | Â | Â | 71 |
Salmonella typhi | Â | Â | 72 |
Histone like DNA-binding protein (HU homolog) | |||
Mycobacterium leprae | Â | Â | 73 |
Mycobacterium leprae | Â | Â | 74 |
Mycobacterium tuberculosis | Â | Â | 75 |
Mycobacterium tuberculosis | Â | Â | 76 |
40S ribosomal protein SA (P40) | |||
Chlorohydra viridissima | Â | Â | 77 |
Strongylocentrotus purpuratus | Â | Â | 78 |
Tripneustes gratilla | Â | Â | 79 |
Urechis caupo | Â | Â | 79 |
Laminin-binding protein | |||
Streptococcus agalactiae | Â | Â | 80 |
Streptococcus agalactiae | Â | Â | 81 |
Streptococcus pyogenes | Â | Â | 82 |
Streptococcus agalactiae | Â | Â | 83 |
Streptococcus agalactiae | Â | Â | 83 |
Streptococcus agalactiae | Â | Â | 83 |
Serine-rich protein (TYE7) | |||
Saccharomyces cerevisiae | Â | Â | 84 |
Saccharomyces cerevisiae | 85 | Â | Â |