Protein name | Description | Molecular function | aCI/PI Time 0 h | aCI/PI Time 15 h | aCI/PI Time 80 h |
---|---|---|---|---|---|
Oxidative stress and mitochondrial metabolism | |||||
Ilv5p | Acetohydroxyacid reductoisomerase | Mitochondrial DNA stability | 0.16 | 2.53 | 10.20 |
Cor1p | Ubiquinol-cytochrome c reductase (bc1 complex) | Electron transport chain | 0.03 | 2.28 | 3.89 |
Pdi1p | Protein disulfide isomerase | Formation of disulfide bonds | Nd | 2.44 | 0.12 |
Mam33p | Mitochondrial protein | Oxidative phosphorylation | Nd | 1.59 | 0.39 |
Ahp1 | Peroxiredoxin type II | Oxidative damage protection | Nd | 0.91 | 0.22 |
Heat shock proteins | |||||
Ssa1p | Heat shock protein 70 | Protein folding | 1.01 | 2.45 | 1.49 |
Mif4p | Heat shock protein 60 | Mitochondrial protein folding | 0.65 | 8.37 | 3.77 |
Ssb1p | Cytoplasmic ATPase | Protein folding | 0.36 | 4.78 | 1.44 |
Sse1p | Heat shock protein 90 | Binds unfolded proteins | 0.06 | 2.30 | 1.20 |
Cpr5p | Peptidyl-prolyl-cis-trans isomerase | Response to unfolded proteins | 0.05 | 0.92 | 0.55 |
Mge1p | Mitochondrial co-chaperone | Folding of Fe/S cluster proteins | Nd | 0.08 | 0.03 |
ATP Metabolism | |||||
Vma1p | Vacuolar H+ATPase | Vacuolar acidification | 0.40 | 4.08 | 0.71 |
Ipp1p | Inorganic pirophosphatase | Exchange of O2 from Pi with water | Nd | 1.96 | 0.86 |
ATp2p | ATP synthase (β-sub F1) | ATP synthesis | Nd | 2.95 | 4.08 |
Tricarboxilic acid cycle | |||||
Mls1p | Malate synthase | Enzyme of the glyoxylate cycle | 0.73 | 0.62 | 9.07 |
Mdh1p | Malate dehydrogenase | Conversion malate and oxaloacetate | Nd | 2.23 | 1.03 |
Cit1p | Citrate synthase | Condensation of acetyl coenzyme A and oxaloacetate to form citrate | Nd | 1.35 | 0.67 |
Aco1p | Aconitase I | Tricarboxilic acid cycle | Nd | 1.23 | 1.36 |
Ach1p | CoA transferase | Acetate utilization | Nd | 0.98 | 4.08 |
Glycolysis and Fermentation | |||||
Tdh3p | Glyceraldehyde-3-phosphate dehydrogenase | Glycolysis | 3.69 | 7.23 | 24.22 |
Eno1p | Enolase I | Glycolysis | 1.17 | 2.86 | 11.12 |
Adh1p | Alcohol dehydrogenase | Alcoholic fermentation | 0.94 | 4.67 | 8.32 |
Pdc1p | Piruvate dehydrogenase | Alcoholic fermentation | 0.53 | 13.21 | 4.48 |
Eno2p | Enolase II | Glycolysis and Gluconeogenesis | 0.34 | 7.67 | 6.25 |
Fba1p | Fructose-1,6-bisphosphate aldolase | Glycolysis | 0.16 | 6.98 | 6.22 |
Cdc19p | Piruvate kinase | Glycolysis | 0.04 | 1.89 | 1.50 |
Ald4p | Aldehyde dehydrogenase | Required for growth on ethanol | Nd | 7.78 | 4.17 |
Hxk1p | Hexokinase | Glucose biosynthesis | Nd | 4.37 | 2.79 |
Gpp1p | DL-glycerol-3-phosphatase | Glycerol biosynthesis | Nd | 2.05 | 1.51 |
Pgk1p | 3-phosphoglycerate kinase | Glycolysis and Gluconeogenesis | Nd | 1.81 | 1.78 |
Tpi1p | Triose phosphate isomerase | Glycolysis | Nd | Nd | 3.21 |
Protein synthesis and amino acid metabolism | |||||
Tef1p | Translational elongation factor EF-1a | Binding of AA-tRNA to ribosomes | 1.36 | 0.85 | 1.15 |
Met6p | Methionine synthase | Methionine synthesis | 0.67 | 2.57 | 1.85 |
Rps5p | Protein component of the 40S ribosome | Protein synthesis | Nd | Nd | 1.57 |