From: Systems solutions by lactic acid bacteria: from paradigms to practice
Function | Paradigm Element [Genes] | Discovery or Exploitations | References |
---|---|---|---|
Replication | pWV01/pSH71 [repAB] | Plasmid Vectors and Copy Number | |
Lactose Metabolism | pLP712 [lacFEG] | Controlled Expression; Food Grade Markers | |
High Frequency Conjugation | pLP712 [cluA] | Clumping and High Frequency Conjugal Transfer | [15] |
Proteinase Production | pWV05 – pSK112 [prtPM] | Chaperon Function; Flavor Engineering | |
Citrate Metabolism | pCT176 [citP] | Citrate Transport; Flavor Engineering | [19] |
Bacteriophage Resistance | pTR2030 [abiA-abiZ] | Bacteriophage Resistant Starters | |
Nisin and Phage Resistance | pNP40 | Bacteriophage Resistance Starters | [23] |
Sucrose-Nisin Transposon | Tn5276 [sac &nis operons] | Conjugal Transfer; Antimicrobial Strains; NICE system] | |
EPS Production | pNZ4000 [eps operon] | EPS Priming Polymerase; Structure Engineering | [27] |
Temperate Phage | Bacteriophage r1t | Temperature Controlled Expression | |
Mucus Binding | GGISL2 [spaCBA-srtA] | Genomic Island for Mucus Binding Pili | [31] |
Phage and Plasmid Resistance | CRISPR-cas operon | Bacteriophage & Plasmid Immunity System | |
Production of SLP | SLP | Phase Variation and SLP Induced DC SIGN signalling |