From: Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again
Stress | Protein/Gene/System (General Role/Description) | Fold Induction | Strain | Ref |
---|---|---|---|---|
Heat | GroEL (chaperone protein) | +49.1 | Lactobacillus paracasei NFBC338 | [37] |
Heat Osmotic | GroEL (chaperone protein) | +15 +3 | Lactobacillus rhamnosus HN001 | [118] |
Heat | clpL1 (Clp ATPase family, members act as chaperones and regulators of proteolysis) | +20 | Lactobacillus rhamnosus E800 | [119] |
Heat, Cold, Ethanol | hsp18.5 (heat shock protein) hsp19.3 (heat shock protein) | nd | Lactobacillus plantarum Lp90 | [41] |
Heat, Cold, Ethanol | hsp18.55 (heat shock protein) | nd | Lactobacillus plantarum Lp90 | [42] |
Heat | DnaK (chaperone protein) GroEL (chaperone protein) ClpE (Clp ATPase family, members act as chaperones and regulators of proteolysis) | +4.4 +3.8 +1.7 | Lactobacillus gasseri ATCC 33323 | [120] |
Heat | FtsH (protease and chaperone activity) | +8 | Lactobacillus plantarum WCFS1 | [121] |
Heat | HtrA (protease and chaperone activity) GroEL (chaperone protein) DnaK (chaperone protein) GrpE (chaperone protein) | +10 -+15 +5 -+10 +10 -+15 +2 -+5 | Bifidobacterium longum 3A | [122] |
Heat | groEl-cspA, (chaperone protein-cold shock protein) groES (chaperone protein) | +12 +8 | Bifidobacterium breve UCC 2003 | [123] |
Heat | clpC (Clp ATPase family, members act as chaperones and regulators of proteolysis) | +15 | Bifidobacterium breve UCC 2003 | [124] |
Heat | clpP operon: clpP1, clpP2 (Clp ATPase family, members act as chaperones and regulators of proteolysis) | +15 | Bifidobacterium breve UCC 2003 | [125] |
Heat Osmotic | hsp20 (heat shock protein) | +28 +25 | Bifidobacterium breve UCC 2003 | [126] |
Temperature downshift | cspA (cold shock protein) | +20 | Lactobacillus bulgaricus VI104 | [127] |
Cold | ClpP (Clp ATPase family, members act as chaperones and regulators of proteolysis) Pyruvate kinase Glycoprotein endopeptidase | ≥2 | Lactobacillus acidophilus RD758 | [128] |
Temperature downshift | cspL (cold shock protein) | +17 | Lactobacillus plantarum NC8 | [46] |
Osmotic | dnaK operon: dnaK, grpE, dnaJ (chaperones), ORF1 (similarity to predicted heat-controlled transcriptional regulators of Mer family) | +15, +14 | Bifidobacterium breve UCC 2003 | [129] |
Osmotic | dnaJ 2 (chaperone) | +4.5 | Bifidobacterium breve UCC 2003 | [130] |
Oxygen | NADH oxidase & NADH peroxidase | Â | Lactobacillus acidophilus 2400 Lactobacillus acidophilus 2409 Bifidobacterium lactis 1941 Bifidobacterium pseudolongum 1944 Bifidobacterium longum 1944 | [103] |
Oxygen | AhpC (alkyl hydroperoxide reductase C22) PNDR (Pyridine nucleotide-disulfide reductase) Dps (DNA-binding ferritin-like protein) NrdA (ribonucleotide reductase) MutT1 (NTP phosphohydrolases) | +10 +2 +1.7 +2 +1.8 | Bifidobacterium longum BBMN68 | [104] |
Bile | HtrA (protease and chaperone activity) DnaK (chaperone protein) GroEL (chaperone protein) | +1.5-+2 +1.5-+2 +1.5-+2 | Bifidobacterium longum 3A | [122] |
Bile | Bsh1 (bile salt hydrolase) | Â | Lactobacillus plantarum WCFS1 | [131] |
Bile | Ctr (cholate transporter) | Â | Bifidobacterium longum NCIMB 702259T | [132] |
Acid | clpL (Clp ATPase family, members act as chaperones and regulators of proteolysis) Ir1516 (putative cell wall-altering esterase) | +2-+3 >5 | Lactobacillus reuteri ATCC 55730 | [133] |
Acid | GrpE (chaperone protein) | >3.5 | Lactobacillus sanfranciscensis CB1 | [134] |
Acid | LBAI524HK (histidine kinase) | Â | Lactobacillus acidophilus NCFM | [135] |
Acid | F 0 F 1 - ATPase operon (involved in ATP synthesis and proton extrusion) | +2 | Lactobacillus acidophilus NCFM/N2 | [136] |
Acid | F 0 F 1 - ATPase operon (involved in ATP synthesis and proton extrusion) | +15 | Bifidobacterium lactis DSM10140 | [137] |