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Figure 6 | Microbial Cell Factories

Figure 6

From: Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surface antigen

Figure 6

Purified VLPs composed of HBsAg. Transmission electron microscopy of negatively stained HBsAg VLPs after purification from detergent-treated cell lysate. Cells were collected after 170 h of growth on methanol and the HBsAg purified from the cell lysate as described in the Materials and Methods section. (A) Survey of negatively stained HBsAg VLPs and (B) close-up view revealing particles of uniform diameter (~22 nm) and approximate icosahedral contour.

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Microbial Cell Factories

ISSN: 1475-2859

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