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Recombinant protein production; Escherichia coli; Silent codon exchange; Synonymous codon; Respiration activity; Metabolic burden; Plasmid copy number
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doi:10.1186/s12934-015-0348-8
BioMed Central
Microbial Cell Factories, doi:10.1186/s12934-015-0348-8
Recombinant protein production; Escherichia coli; Silent codon exchange; Synonymous codon; Respiration activity; Metabolic burden; Plasmid copy number
A particular silent codon exchange in a recombinant gene greatly influences host cell metabolic activity
Natalie Rahmen
Christian D. Schlupp
Hitoshi Mitsunaga
Alexander Fulton
Tita Aryani
Lara Esch
Ulrich Schaffrath
Eiichiro Fukuzaki
Karl-Erich Jaeger
Jochen Büchs
10.1186/s12934-015-0348-8
2010-04-23
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