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  1. The ability of fungal cellobiose dehydrogenase (CDH) to generate H2O2in-situ is highly interesting for biotechnological applications like cotton bleaching, laundry detergents or antimicrobial functionalization of...

    Authors: Christoph Sygmund, Paul Santner, Iris Krondorfer, Clemens K Peterbauer, Miguel Alcalde, Gibson S Nyanhongo, Georg M Guebitz and Roland Ludwig
    Citation: Microbial Cell Factories 2013 12:38
  2. Disulfide-rich proteins or DRPs are versatile bioactive compounds that encompass a wide variety of pharmacological, therapeutic, and/or biotechnological applications. Still, the production of DRPs in sufficien...

    Authors: Hervé Nozach, Carole Fruchart-Gaillard, François Fenaille, Fabrice Beau, Oscar Henrique Pereira Ramos, Badreddine Douzi, Natalie J Saez, Mireille Moutiez, Denis Servent, Muriel Gondry, Robert Thaï, Philippe Cuniasse, Renaud Vincentelli and Vincent Dive
    Citation: Microbial Cell Factories 2013 12:37
  3. To isolate over-secretors, we subjected to saturation mutagenesis, a strain of P.pastoris exporting E. coli alkaline phosphatase (EAP) fused to the secretory domain of the yeast α factor pheromone through cellula...

    Authors: Ferez S Nallaseth and Stephen Anderson
    Citation: Microbial Cell Factories 2013 12:36
  4. Beta-glucosidase inhibitors are being extensively studied for use as anti-diabetics, anti-obesity and anti-tumour compounds. So far, these compounds have been reported in large numbers from plants, mushrooms, ...

    Authors: Sony Pandey, Ayinampudi Sree, Soumya Suchismita Dash, Dipti Priya Sethi and Lipsa Chowdhury
    Citation: Microbial Cell Factories 2013 12:35
  5. Kluyveromyces marxianus combines the ease of genetic manipulation and fermentation with the ability to efficiently secrete high molecular weight proteins, performing eukaryotic post-translational modifications. I...

    Authors: Stefano Raimondi, Elena Zanni, Alberto Amaretti, Claudio Palleschi, Daniela Uccelletti and Maddalena Rossi
    Citation: Microbial Cell Factories 2013 12:34
  6. One of the main challenges for heterologous protein production by the methylotrophic yeast Pichia pastoris at large-scale is related to its high oxygen demand. A promising solution is a co-feeding strategy based ...

    Authors: Hongxing Niu, Laurent Jost, Nathalie Pirlot, Hosni Sassi, Marc Daukandt, Christian Rodriguez and Patrick Fickers
    Citation: Microbial Cell Factories 2013 12:33
  7. Staphylococcus aureus is unrestrictedly found in humans and in animal species that maintain thermal homeostasis. Inadequate cleaning of processing equipment or inappropriate handling can contaminate processed foo...

    Authors: Giselli Fernandes Asensi, Nathalia Ferrari Fonseca de Sales, Fabiano Ferreira Dutra, Daniel Ferreira Feijó, Marcelo Torres Bozza, Robert G Ulrich, Anderson Miyoshi, Katia de Morais, Vasco Ariston de Carvalho Azevedo, Joab Trajano Silva, Yves Le Loir and Vânia Margaret Flosi Paschoalin
    Citation: Microbial Cell Factories 2013 12:32
  8. Fungal polyketides include commercially important pharmaceuticals and food additives, e.g. the cholesterol-lowering statins and the red and orange monascus pigments. Presently, production relies on isolation o...

    Authors: Peter Rugbjerg, Michael Naesby, Uffe H Mortensen and Rasmus JN Frandsen
    Citation: Microbial Cell Factories 2013 12:31
  9. Elevated pressure, elevated oxygen tension (DOT) and elevated carbon dioxide tension (DCT) are readily encountered at the bottom of large industrial bioreactors and during bioprocesses where pressure is applie...

    Authors: Stéphanie Follonier, Isabel F Escapa, Pilar M Fonseca, Bernhard Henes, Sven Panke, Manfred Zinn and María Auxiliadora Prieto
    Citation: Microbial Cell Factories 2013 12:30
  10. Finely regulating the carbon flux through the glycerol pathway by regulating the expression of the rate controlling enzyme, glycerol-3-phosphate dehydrogenase (GPDH), has been a promising approach to redirect ...

    Authors: Julien Pagliardini, Georg Hubmann, Sandrine Alfenore, Elke Nevoigt, Carine Bideaux and Stephane E Guillouet
    Citation: Microbial Cell Factories 2013 12:29
  11. Yeast is recognized as a generally safe microorganism and is utilized for the production of pharmaceutical products, including vaccines. We previously showed that expression of human immunodeficiency virus typ...

    Authors: Naoki Tomo, Toshiyuki Goto and Yuko Morikawa
    Citation: Microbial Cell Factories 2013 12:28
  12. Pachysolen tannophilus is a non-conventional yeast, which can metabolize many of the carbon sources found in low cost feedstocks including glycerol and xylose. The xylose utilisation pathways have been extensivel...

    Authors: Xiaoying Liu, Uffe Hasbro Mortensen and Mhairi Workman
    Citation: Microbial Cell Factories 2013 12:27
  13. Production of recombinant proteins in bacteria for academic and commercial purposes is a well established field; however the outcomes of process developments for specific proteins are still often unpredictable...

    Authors: Simone Balzer, Veronika Kucharova, Judith Megerle, Rahmi Lale, Trygve Brautaset and Svein Valla
    Citation: Microbial Cell Factories 2013 12:26
  14. Biologically active inclusion bodies (IBs) have gained much attention in recent years. Fusion with IB-inducing partner has been shown to be an efficient strategy for generating active IBs. To make full use of ...

    Authors: Ziliang Huang, Chong Zhang, Shuo Chen, Fengchun Ye and Xin-Hui Xing
    Citation: Microbial Cell Factories 2013 12:25
  15. In Escherichia coli many heterologous proteins are produced in the periplasm. To direct these proteins to the periplasm, they are equipped with an N-terminal signal sequence so that they can traverse the cytoplas...

    Authors: Susan Schlegel, Edurne Rujas, Anders Jimmy Ytterberg, Roman A Zubarev, Joen Luirink and Jan-Willem de Gier
    Citation: Microbial Cell Factories 2013 12:24
  16. In last decade spores have been successfully used as a surface display platform. Various peptides or proteins were displayed this way as functional enzymes or antigens. Nearly all attempts involved use of thre...

    Authors: Krzysztof Hinc, Adam Iwanicki and Michał Obuchowski
    Citation: Microbial Cell Factories 2013 12:22
  17. Silk-elastin-like proteins (SELPs) combining the physicochemical and biological properties of silk and elastin have a high potential for use in the pharmaceutical, regenerative medicine and materials fields. T...

    Authors: Tony Collins, João Azevedo-Silva, André da Costa, Fernando Branca, Raul Machado and Margarida Casal
    Citation: Microbial Cell Factories 2013 12:21
  18. Klebsiella oxytoca, a Gram-negative, rod-shaped, and facultative anaerobic bacterium, is one of the most promising 2,3-butanediol (2,3-BD) producers. In order to improve the metabolic performance of K. oxytoca as...

    Authors: Jong Myoung Park, Hyohak Song, Hee Jong Lee and Doyoung Seung
    Citation: Microbial Cell Factories 2013 12:20
  19. The Bacillus subtilis genome-reduced strain MGB874 exhibits enhanced production of exogenous extracellular enzymes under batch fermentation conditions. We predicted that deletion of the gene for RocG, a bi-functi...

    Authors: Kenji Manabe, Yasushi Kageyama, Takuya Morimoto, Eri Shimizu, Hiroki Takahashi, Shigehiko Kanaya, Katsutoshi Ara, Katsuya Ozaki and Naotake Ogasawara
    Citation: Microbial Cell Factories 2013 12:18
  20. The understanding of protein aggregation is a central issue in different fields of protein science, from the heterologous protein production in biotechnology to amyloid aggregation in several neurodegenerative...

    Authors: Diletta Ami, Antonino Natalello, Marina Lotti and Silvia Maria Doglia
    Citation: Microbial Cell Factories 2013 12:17
  21. Adhesins of pathogens recognise the glycans on the host cell and mediate adherence. They are also crucial for determining the tissue preferences of pathogens. Currently, glyco-nanomaterials provide potential t...

    Authors: Klaudia Talafová, Eva Hrabárová, Dušan Chorvát and Jozef Nahálka
    Citation: Microbial Cell Factories 2013 12:16
  22. Hydroxycinnamates (HCs) are mainly produced in plants. Caffeic acid (CA), p-coumaric acid (PA), ferulic acid (FA) and sinapic acid (SA) are members of the HC family. The consumption of HC by human might prevent c...

    Authors: Bong-Gyu Kim, Woo Dam Jung, Hyejung Mok and Joong-Hoon Ahn
    Citation: Microbial Cell Factories 2013 12:15
  23. Cellulosic biomass is considered as a promising alternative to fossil fuels, but its recalcitrant nature and high cost of cellulase are the major obstacles to utilize this material. Consolidated bioprocessing ...

    Authors: Sujin Kim, Seung-Ho Baek, Kyusung Lee and Ji-Sook Hahn
    Citation: Microbial Cell Factories 2013 12:14
  24. The red yeast Xanthophyllomyces dendrorhous is a natural producer of the carotenoid astaxanthin. Because of its high flux, the native terpene pathway leading to the production of the tetraterpene is of particular...

    Authors: Elena Melillo, Rita Setroikromo, Wim J Quax and Oliver Kayser
    Citation: Microbial Cell Factories 2013 12:13
  25. In past years research has focused on the development of alternative Gram positive bacterial expression systems to produce industrially relevant proteins. Brevibacillus choshinensis is an easy to handle non-sporu...

    Authors: Nunzia D’Urzo, Manuele Martinelli, Chiara Nenci, Cecilia Brettoni, John L Telford and Domenico Maione
    Citation: Microbial Cell Factories 2013 12:12
  26. Marine environments are the widest fonts of biodiversity representing a resource of both unexploited or unknown microorganisms and new substances having potential applications. Among microbial products, exopol...

    Authors: Silvia Silvi, Paolo Barghini, Arianna Aquilanti, Belen Juarez-Jimenez and Massimiliano Fenice
    Citation: Microbial Cell Factories 2013 12:10
  27. Phosphatidic acid phosphatase (PAP, EC 3.1.3.4) catalyzes the dephosphorylation of phosphatidate yielding diacylglycerol (DAG), the lipid precursor for triacylglycerol (TAG) biosynthesis. Despite the importanc...

    Authors: Santiago Comba, Simón Menendez-Bravo, Ana Arabolaza and Hugo Gramajo
    Citation: Microbial Cell Factories 2013 12:9
  28. Biocatalyst improvement through molecular and recombinant means should be complemented with efficient process design to facilitate process feasibility and improve process economics. This study focused on under...

    Authors: Oluwafemi A Olaofe, Caryn J Fenner, RamaKrishna Gudiminchi, Martha S Smit and Susan TL Harrison
    Citation: Microbial Cell Factories 2013 12:8
  29. Due to its abundance and low-price, glycerol has become an attractive carbon source for the industrial production of value-added fuels and chemicals. This work reports the engineering of E. coli for the efficient...

    Authors: Suman Mazumdar, Matthew D Blankschien, James M Clomburg and Ramon Gonzalez
    Citation: Microbial Cell Factories 2013 12:7
  30. Repressible promoters are a useful tool for down-regulating the expression of genes, especially those that affect cell viability, in order to study cell physiology. They are also popular in biotechnological pr...

    Authors: Marizela Delic, Diethard Mattanovich and Brigitte Gasser
    Citation: Microbial Cell Factories 2013 12:6
  31. Inducible high-level expression is favoured for recombinant protein production in Pichia pastoris. Therefore, novel regulated promoters are desired, ideally repressing heterologous gene expression during initial ...

    Authors: Roland Prielhofer, Michael Maurer, Joachim Klein, Jana Wenger, Christoph Kiziak, Brigitte Gasser and Diethard Mattanovich
    Citation: Microbial Cell Factories 2013 12:5
  32. Conversion of industrial processes to more nature-friendly modes is a crucial subject for achieving sustainable development. Utilization of hydrogen-oxidation reactions by hydrogenase as a driving force of bio...

    Authors: Takahiro Oda, Koji Oda, Hiroaki Yamamoto, Akinobu Matsuyama, Masaharu Ishii, Yasuo Igarashi and Hirofumi Nishihara
    Citation: Microbial Cell Factories 2013 12:2
  33. Yeast viability and vitality are essential for different industrial processes where the yeast Saccharomyces cerevisiae is used as a biotechnological tool. Therefore, the decline of yeast biological functions duri...

    Authors: Helena Orozco, Emilia Matallana and Agustín Aranda
    Citation: Microbial Cell Factories 2013 12:1
  34. Candida parapsilosis CCTCC M203011 catalyzes the stereoinversion of (R)-1-phenyl-1,2-ethanediol (PED) through oxidation and reduction. Its NAD+-linked (R)-carbonyl reductase (RCR) catalyzes the oxidization of (R)...

    Authors: Rongzhen Zhang, Yan Xu, Rong Xiao, Botao Zhang and Lei Wang
    Citation: Microbial Cell Factories 2012 11:167
  35. An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms....

    Authors: Anna Villar-Piqué and Salvador Ventura
    Citation: Microbial Cell Factories 2012 11:166
  36. Laccase-like multicopper oxidases have been reported in several Aspergillus species but they remain uncharacterized. The biocatalytic potential of the Aspergillus niger fungal pigment multicopper oxidases McoA an...

    Authors: JuanAntonio Tamayo-Ramos, Willem JH van Berkel and Leo H de Graaff
    Citation: Microbial Cell Factories 2012 11:165
  37. The use of lignocellulosic materials for second generation ethanol production would give several advantages such as minimizing the conflict between land use for food and fuel production, providing less expensi...

    Authors: Antonella Amore, Olimpia Pepe, Valeria Ventorino, Leila Birolo, Chiara Giangrande and Vincenza Faraco
    Citation: Microbial Cell Factories 2012 11:164
  38. Escherichia coli is one of the best studied microorganisms and finds multiple applications especially as tool in the heterologous production of interesting proteins of other organisms. The heterologous expression...

    Authors: Franziska L Lederer, Tobias J Günther, Ulrike Weinert, Johannes Raff and Katrin Pollmann
    Citation: Microbial Cell Factories 2012 11:163
  39. Terpenoids and isoprenoids are an important class of natural products, which includes currently used drugs, high value bioactive and industrial compounds, and fuel candidates. Due to their industrial applicati...

    Authors: Codruta Ignea, Fotini A Trikka, Ioannis Kourtzelis, Anagnostis Argiriou, Angelos K Kanellis, Sotirios C Kampranis and Antonios M Makris
    Citation: Microbial Cell Factories 2012 11:162
  40. Probiotic bacteria are increasingly used as immunomodulatory agents. Yet detailed molecular knowledge on the immunomodulatory molecules of these bacteria is lagging behind. Lipoteichoic acid (LTA) is considere...

    Authors: Ingmar JJ Claes, Marijke E Segers, Tine LA Verhoeven, Michiel Dusselier, Bert F Sels, Sigrid CJ De Keersmaecker, Jos Vanderleyden and Sarah Lebeer
    Citation: Microbial Cell Factories 2012 11:161
  41. The microbial synthesis of fuels, commodity chemicals, and bioactive compounds necessitates the assemblage of multiple enzyme activities to carry out sequential chemical reactions, often via substrate channeli...

    Authors: Andrew S Wieczorek and Vincent JJ Martin
    Citation: Microbial Cell Factories 2012 11:160
  42. Thermobacillus xylanilyticus is a thermophilic and highly xylanolytic bacterium. It produces robust and stable enzymes, including glycoside hydrolases and esterases, which are of special interest for the developm...

    Authors: Harivony Rakotoarivonina, Béatrice Hermant, Nina Monthe and Caroline Rémond
    Citation: Microbial Cell Factories 2012 11:159
  43. Autotransporters represent a widespread family of secreted proteins in Gram-negative bacteria. Their seemingly easy secretion mechanism and modular structure make them interesting candidates for cell surface d...

    Authors: Toon Nicolay, Lynn Lemoine, Elke Lievens, Sam Balzarini, Jos Vanderleyden and Stijn Spaepen
    Citation: Microbial Cell Factories 2012 11:158

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