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  1. Protein production as secretory-form is a powerful tool in industrial enzyme production due to the simple purification procedure. Streptomyces lividans is a versatile host for secretory production of useful prote...

    Authors: Takaya Miyazaki, Shuhei Noda, Tsutomu Tanaka and Akihiko Kondo
    Citation: Microbial Cell Factories 2013 12:88
  2. Production of bioethanol from lignocellulosic biomass requires the development of robust microorganisms that can tolerate the stressful conditions prevailing in lignocellulosic hydrolysates. Several inhibitors...

    Authors: Magnus Ask, Valeria Mapelli, Heidi Höck, Lisbeth Olsson and Maurizio Bettiga
    Citation: Microbial Cell Factories 2013 12:87
  3. During the last two decades many efforts have been directed towards obtaining efficient microbial processes for the production of shikimic acid (SA); however, feeding high amounts of substrate to increase the ...

    Authors: Alberto Rodriguez, Juan A Martínez, José L Báez-Viveros, Noemí Flores, Georgina Hernández-Chávez, Octavio T Ramírez, Guillermo Gosset and Francisco Bolivar
    Citation: Microbial Cell Factories 2013 12:86
  4. Drug-resistance and therapy failure due to drug-drug interactions are the main challenges in current treatment against Human Immunodeficiency Virus (HIV) infection. As such, there is a continuous need for the ...

    Authors: Javier P Martinez, Bettina Hinkelmann, Eric Fleta-Soriano, Heinrich Steinmetz, Rolf Jansen, Juana Diez, Ronald Frank, Florenz Sasse and Andreas Meyerhans
    Citation: Microbial Cell Factories 2013 12:85
  5. Heterologous microbial production of rare plant terpenoids of medicinal or industrial interest is attracting more and more attention but terpenoid yields are still low. Escherichia coli and Saccharomyces cerevisi...

    Authors: Evamaria Gruchattka, Oliver Hädicke, Steffen Klamt, Verena Schütz and Oliver Kayser
    Citation: Microbial Cell Factories 2013 12:84
  6. Optimization of industrial biomass directed processes requires the highest biomass yield as possible. Yet, some useful yeasts like Saccharomyces cerevisiae are subject to the Crabtree effect under glucose excess....

    Authors: Jillian Marc, David Feria-Gervasio, Jean-Roch Mouret and Stéphane E Guillouet
    Citation: Microbial Cell Factories 2013 12:83
  7. Glycolic acid is a C2 hydroxy acid that is a widely used chemical compound. It can be polymerised to produce biodegradable polymers with excellent gas barrier properties. Currently, glycolic acid is produced i...

    Authors: Outi M Koivistoinen, Joosu Kuivanen, Dorothee Barth, Heidi Turkia, Juha-Pekka Pitkänen, Merja Penttilä and Peter Richard
    Citation: Microbial Cell Factories 2013 12:82
  8. The anchoring motif is one of the most important aspects of cell surface display as well as efficient and stable display of target proteins. Thus, there is currently a need for the identification and isolation...

    Authors: Tae Jung Park, Nam Su Heo, Sung Sun Yim, Jong Hyun Park, Ki Jun Jeong and Sang Yup Lee
    Citation: Microbial Cell Factories 2013 12:81
  9. Succinic acid (SA) has become a prominent biobased platform chemical with global production quantities increasing annually. Numerous genetically modified E. coli strains have been developed with the main aim of i...

    Authors: Carel D van Heerden and Willie Nicol
    Citation: Microbial Cell Factories 2013 12:80
  10. Nattokinases/Subtilisins (EC 3.4.21.62) belong to the second large family of serine proteases, which gain significant attention and play important role in many biotechnology processes. Thus, a number of nattok...

    Authors: Thao Thi Nguyen, Thi Dinh Quyen and Hoang Thanh Le
    Citation: Microbial Cell Factories 2013 12:79
  11. Mannanase is an enzyme that can catalyze random hydrolysis of beta-1,4-mannosidic linkages in the main chain of mannans, glucomannans and galactomannans which are the key polymers in hemicellulose. It has been...

    Authors: Haiyan Zhou, Yong Yang, Xu Nie, Wenjiao Yang and Yongyao Wu
    Citation: Microbial Cell Factories 2013 12:78
  12. Polyketides are one of the most important classes of secondary metabolites and usually make good drugs. Currently, heterologous production of fungal polyketides for developing a high potential industrial appli...

    Authors: Limei Gao, Menghao Cai, Wei Shen, Siwei Xiao, Xiangshan Zhou and Yuanxing Zhang
    Citation: Microbial Cell Factories 2013 12:77
  13. Monoterpenes are a class of natural C10 compounds with a range of potential applications including use as fuel additives, fragrances, and chemical feedstocks. Biosynthesis of monoterpenes in heterologous systems ...

    Authors: James BYH Behrendorff, Claudia E Vickers, Panagiotis Chrysanthopoulos and Lars K Nielsen
    Citation: Microbial Cell Factories 2013 12:76
  14. The use of microorganisms in the synthesis of nanoparticles emerges as an eco-friendly and exciting approach, for production of nanoparticles due to its low energy requirement, environmental compatibility, red...

    Authors: Daniela N Correa-Llantén, Sebastian A Muñoz-Ibacache, Miguel E Castro, Patricio A Muñoz and Jenny M Blamey
    Citation: Microbial Cell Factories 2013 12:75
  15. A large range of genetic tools has been developed for the optimal design and regulation of complex metabolic pathways in bacteria. However, fewer tools exist in yeast that can precisely tune the expression of ...

    Authors: Erwin Lamping, Masakazu Niimi and Richard D Cannon
    Citation: Microbial Cell Factories 2013 12:74
  16. Fab antibody fragments in E. coli are usually directed to the oxidizing periplasmic space for correct folding. From periplasm Fab fragments may further leak into extracellular medium. Information on the cultivati...

    Authors: Kaisa Ukkonen, Johanna Veijola, Antti Vasala and Peter Neubauer
    Citation: Microbial Cell Factories 2013 12:73
  17. The genome of the important industrial host Bacillus subtilis does not encode the glyoxylate shunt, which is necessary to utilize overflow metabolites, like acetate or acetoin, as carbon source. In this study, th...

    Authors: Johannes Kabisch, Isabel Pratzka, Hanna Meyer, Dirk Albrecht, Michael Lalk, Armin Ehrenreich and Thomas Schweder
    Citation: Microbial Cell Factories 2013 12:72
  18. The human gut is one of the most complex ecosystems, composed of 1013-1014 microorganisms which play an important role in human health. In addition, some food products contain live bacteria which transit through ...

    Authors: Rebeca Martín, Sylvie Miquel, Jonathan Ulmer, Noura Kechaou, Philippe Langella and Luis G Bermúdez-Humarán
    Citation: Microbial Cell Factories 2013 12:71
  19. Conjugated linoleic acid (CLA) has been extensively studied for decades because of its health benefits including cancer prevention, anti-atherogenic and anti-obesity effects, and modulation of the immune syste...

    Authors: Baixi Zhang, Haiqin Chen, Min Li, Zhennan Gu, Yuanda Song, Colin Ratledge, Yong Q Chen, Hao Zhang and Wei Chen
    Citation: Microbial Cell Factories 2013 12:70
  20. Previously, we distinguished the Escherichia coli type II cytoplasmic membrane translocation pathways of Tat, Yid, and Sec for unfolded and folded soluble target proteins. The translocation of folded protein to t...

    Authors: Sang Jun Lee, Eun Hee Park, Young Ok Kim, Bo Hye Nam and Dong Gyun Kim
    Citation: Microbial Cell Factories 2013 12:68
  21. The lac operon provides cells with the ability to switch from glucose to lactose metabolism precisely when necessary. This metabolic switch is mediated by the lac repressor (LacI), which in the absence of lactose...

    Authors: Pietro Gatti-Lafranconi, Willem P Dijkman, Sean RA Devenish and Florian Hollfelder
    Citation: Microbial Cell Factories 2013 12:67
  22. Numerous studies have examined the direct fermentation of cellulosic materials by cellulase-expressing yeast; however, ethanol productivity in these systems has not yet reached an industrial level. Certain mic...

    Authors: Yuki Nakatani, Ryosuke Yamada, Chiaki Ogino and Akihiko Kondo
    Citation: Microbial Cell Factories 2013 12:66
  23. Ribosome assembly cofactor RimP is one of the auxiliary proteins required for maturation of the 30S subunit in Escherichia coli. Although RimP in protein synthesis is important, its role in secondary metabolites ...

    Authors: Yuanyuan Pan, Cheng Lu, Hailing Dong, Lingjun Yu, Gang Liu and Huarong Tan
    Citation: Microbial Cell Factories 2013 12:65
  24. Oats contain hydroxycinnamoyl anthranilates, also named avenanthramides (Avn), which have beneficial health properties because of their antioxidant, anti-inflammatory, and antiproliferative effects. The microb...

    Authors: Aymerick Eudes, Darmawi Juminaga, Edward E K Baidoo, F William Collins, Jay D Keasling and Dominique Loqué
    Citation: Microbial Cell Factories 2013 12:62

    The Erratum to this article has been published in Microbial Cell Factories 2014 13:8

  25. The optimization of metabolic pathways is critical for efficient and economical production of biofuels and specialty chemicals. One such significant pathway is the cellobiose utilization pathway, identified as...

    Authors: Dawn T Eriksen, Pei Chiun Helen Hsieh, Patrick Lynn and Huimin Zhao
    Citation: Microbial Cell Factories 2013 12:61
  26. Metabolic engineering projects often require integration of multiple genes in order to control the desired phenotype. However, this often requires iterative rounds of engineering because many current insertion...

    Authors: Suriana Sabri, Jennifer A Steen, Mareike Bongers, Lars K Nielsen and Claudia E Vickers
    Citation: Microbial Cell Factories 2013 12:60
  27. L-ascorbic acid (L-AA) is naturally synthesized in plants from D-glucose by 10 steps pathway. The pathway branch to synthesize L-galactose, the key intermediate for L-ascorbic acid biosynthesis, has been recen...

    Authors: Júlio César Câmara Rosa, Lívia Tavares Colombo, Mariana Caroline Tocantins Alvim, Nelson Avonce, Patrick Van Dijck and Flávia Maria Lopes Passos
    Citation: Microbial Cell Factories 2013 12:59
  28. In the biopharmaceutical industry, Escherichia coli (E. coli) strains are among the most frequently used bacterial hosts for producing recombinant proteins because they allow a simple process set-up and they are ...

    Authors: Karoline Marisch, Karl Bayer, Monika Cserjan-Puschmann, Markus Luchner and Gerald Striedner
    Citation: Microbial Cell Factories 2013 12:58
  29. Polylactic acid (PLA), a biodegradable polymer, has the potential to replace (at least partially) traditional petroleum-based plastics, minimizing “white pollution”. However, cost-effective production of optic...

    Authors: Jinfang Zhao, Liyuan Xu, Yongze Wang, Xiao Zhao, Jinhua Wang, Erin Garza, Ryan Manow and Shengde Zhou
    Citation: Microbial Cell Factories 2013 12:57
  30. L(-)-carnitine production has been widely studied because of its beneficial properties on various diseases and dysfunctions. Enterobacteria possess a specific biotransformation pathway which can be used for th...

    Authors: Paula Arense, Vicente Bernal, Daniël Charlier, José Luis Iborra, Maria Remedios Foulquié-Moreno and Manuel Cánovas
    Citation: Microbial Cell Factories 2013 12:56
  31. Precise regulation of DNA replication is necessary to ensure the inheritance of genetic features by daughter cells after each cell division. Therefore, determining how the regulatory processes operate to contr...

    Authors: Sylwia Barańska, Monika Glinkowska, Anna Herman-Antosiewicz, Monika Maciąg-Dorszyńska, Dariusz Nowicki, Agnieszka Szalewska-Pałasz, Alicja Węgrzyn and Grzegorz Węgrzyn
    Citation: Microbial Cell Factories 2013 12:55
  32. Numerous microorganisms accumulate polyesters classified as polyhydroxyalkanoates (PHAs) as carbon and energy storage material when the growth condition is unfavorable in the presence of excess carbon source. ...

    Authors: Gi Na Lee and Jonguk Na
    Citation: Microbial Cell Factories 2013 12:54
  33. Polylactic acid is a renewable raw material that is increasingly used in the manufacture of bioplastics, which offers a more sustainable alternative to materials derived from fossil resources. Both lactic acid...

    Authors: Marja Ilmén, Kari Koivuranta, Laura Ruohonen, Vineet Rajgarhia, Pirkko Suominen and Merja Penttilä
    Citation: Microbial Cell Factories 2013 12:53
  34. FK506 is an important immunosuppressant, which can be produced by Streptomyces tsukubaensis. However, the production capacity of the strain is very low. Hereby, a computational guided engineering approach was pro...

    Authors: Di Huang, Shanshan Li, Menglei Xia, Jianping Wen and Xiaoqiang Jia
    Citation: Microbial Cell Factories 2013 12:52
  35. Novel analytical tools, which shorten the long and costly development cycles of biopharmaceuticals are essential. Metabolic flux analysis (MFA) shows great promise in improving our understanding of the metabol...

    Authors: Mariana L Fazenda, Joao ML Dias, Linda M Harvey, Alison Nordon, Ruan Edrada-Ebel, David LittleJohn and Brian McNeil
    Citation: Microbial Cell Factories 2013 12:51
  36. Accumulation of inorganic polyphosphate (polyP), a persistent trait throughout the whole Tree of Life, is claimed to play a fundamental role in enduring environmental insults in a large variety of microorganis...

    Authors: Pablo I Nikel, Max Chavarría, Esteban Martínez-García, Anne C Taylor and Víctor de Lorenzo
    Citation: Microbial Cell Factories 2013 12:50
  37. In current protein research, a limitation still is the production of active recombinant proteins or native protein associations to assess their function. Especially the localization and analysis of protein-com...

    Authors: Thorben Dammeyer, Kenneth N Timmis and Philip Tinnefeld
    Citation: Microbial Cell Factories 2013 12:49
  38. Metabolic flexibility may be generally defined as “the capacity for the organism to adapt fuel oxidation to fuel availability”. The metabolic diversification strategies used by individual bacteria vary greatly...

    Authors: Michelle M O’Donnell, Paul W O’Toole and Reynolds Paul Ross
    Citation: Microbial Cell Factories 2013 12:48
  39. In vivo recombination of overlapping DNA fragments for assembly of large DNA constructs in the yeast Saccharomyces cerevisiae holds great potential for pathway engineering on a small laboratory scale as well as f...

    Authors: Niels GA Kuijpers, Daniel Solis-Escalante, Lizanne Bosman, Marcel van den Broek, Jack T Pronk, Jean-Marc Daran and Pascale Daran-Lapujade
    Citation: Microbial Cell Factories 2013 12:47
  40. Glycosaminoglycans, such as hyaluronic acid, heparin, and chondroitin sulfate, are among the top ranked products in industrial biotechnology for biomedical applications, with a growing world market of billion ...

    Authors: Donatella Cimini, Mario De Rosa, Elisabetta Carlino, Alessandro Ruggiero and Chiara Schiraldi
    Citation: Microbial Cell Factories 2013 12:46
  41. p-Hydroxycinnamic acid (pHCA) is an aromatic compound that serves as a starting material for the production of many commercially valuable chemicals, such as fragrances and pharmaceuticals, and is also used in t.....

    Authors: Yoshifumi Kawai, Shuhei Noda, Chiaki Ogino, Yasunobu Takeshima, Naoko Okai, Tsutomu Tanaka and Akihiko Kondo
    Citation: Microbial Cell Factories 2013 12:45
  42. Extracts and products (roots and/or aerial parts) from Echinacea ssp. represent a profitable market sector for herbal medicines thanks to different functional features. Alkamides and polyacetylenes, phenols like ...

    Authors: Carlo Giuseppe Rizzello, Rossana Coda, Davinia Sánchez Macías, Daniela Pinto, Barbara Marzani, Pasquale Filannino, Giammaria Giuliani, Vito Michele Paradiso, Raffaella Di Cagno and Marco Gobbetti
    Citation: Microbial Cell Factories 2013 12:44
  43. Many proteins and peptides have been used in therapeutic or industrial applications. They are often produced in microbial production hosts by fermentation. Robust protein production in the hosts and efficient ...

    Authors: Neeraj Pandey, Annapurna Sachan, Qi Chen, Kristin Ruebling-Jass, Ritu Bhalla, Kiran Kumar Panguluri, Pierre E Rouviere and Qiong Cheng
    Citation: Microbial Cell Factories 2013 12:43
  44. The bacterium Escherichia coli can be grown employing various carbohydrates as sole carbon and energy source. Among them, glucose affords the highest growth rate. This sugar is nowadays widely employed as raw mat...

    Authors: Laura G Fuentes, Alvaro R Lara, Luz M Martínez, Octavio T Ramírez, Alfredo Martínez, Francisco Bolívar and Guillermo Gosset
    Citation: Microbial Cell Factories 2013 12:42
  45. Current methods of ethanol production from lignocelluloses generate a mixture of sugars, primarily glucose and xylose; the fermentation cells are always exposed to stresses like high temperature and low nutrit...

    Authors: Xi Zhang, Tianyv Wang, Wen Zhou, Xianghui Jia and Haoyong Wang
    Citation: Microbial Cell Factories 2013 12:41
  46. The trisaccharide 2-fucosyllactose (2-FL) is one of the most abundant oligosaccharides found in human milk. Due to its prebiotic and anti-infective properties, 2-FL is discussed as nutritional additive for inf...

    Authors: Florian Baumgärtner, Lyudmila Seitz, Georg A Sprenger and Christoph Albermann
    Citation: Microbial Cell Factories 2013 12:40

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