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  1. The modification of glucose import capacity is an engineering strategy that has been shown to improve the characteristics of Escherichia coli as a microbial factory. A reduction in glucose import capacity can hav...

    Authors: Juan Carlos Fragoso-Jiménez, Rosa María Gutierrez-Rios, Noemí Flores, Alfredo Martinez, Alvaro R. Lara, Frank Delvigne and Guillermo Gosset
    Citation: Microbial Cell Factories 2022 21:189
  2. The anthraquinone-fused 10-membered enediynes (AFEs), represented by tiancimycins (TNMs), possess a unique structural feature and promising potentials as payloads of antitumor antibody–drug conjugates. Despite...

    Authors: Manxiang Zhu, Fan Zhang, Ting Gan, Jing Lin, Yanwen Duan and Xiangcheng Zhu
    Citation: Microbial Cell Factories 2022 21:188
  3. The lipopeptides produced by Streptomyces bikiniensis have a significant inhibitory effect on Magnaporthe oryzae, but the low yield limits its application. In this study, the anti-M. oryzae activity of the broth ...

    Authors: Wei Liu, Jiawen Wang, Huaqian Zhang, Xiaohua Qi and Chunmei Du
    Citation: Microbial Cell Factories 2022 21:187
  4. Amyrin is an important triterpenoid and precursor to a wide range of cosmetic, pharmaceutical and nutraceutical products. In this study, we metabolically engineered the oleaginous yeast, Yarrowia lipolytica to pr...

    Authors: Jing Kong, Lin Miao, Zhihui Lu, Shuhui Wang, Baixiang Zhao, Cuiying Zhang, Dongguang Xiao, Desmond Teo, Susanna Su Jan Leong, Adison Wong and Aiqun Yu
    Citation: Microbial Cell Factories 2022 21:186
  5. Swine influenza A virus (swIAV) is a major concern for the swine industry owing to its highly contagious nature and acute viral disease. Currently, most commercial swIAV vaccines are traditional inactivated vi...

    Authors: Yufei Zhang, Li Yang, Jiali Zhang, Kun Huang, Xiaomei Sun, Ying Yang, Ting Wang, Qiang Zhang, Zhong Zou and Meilin Jin
    Citation: Microbial Cell Factories 2022 21:185
  6. Efficient upgrading of inferior agro-industrial resources and production of bio-based chemicals through a simple and environmentally friendly biotechnological approach is interesting Lactobionic acid is a vers...

    Authors: Jiawei Wu, Peng Liu, Zhaojuan Zheng and Jia Ouyang
    Citation: Microbial Cell Factories 2022 21:184
  7. Fed-batch mode is the standard culture technology for industrial bioprocesses. Nevertheless, most of the early-stage cell and process development is carried out in batch cultures, which can bias the initial se...

    Authors: Daniela Velazquez, Juan-Carlos Sigala, Luz María Martínez, Paul Gaytán, Guillermo Gosset and Alvaro R. Lara
    Citation: Microbial Cell Factories 2022 21:183
  8. The methylotrophic yeast Pichia pastoris is considered as an ideal host for the production of recombinant proteins and chemicals. However, low homologous recombination (HR) efficiency hinders its precise and exte...

    Authors: Kun Zhang, Xingpeng Duan, Peng Cai, Linhui Gao, Xiaoyan Wu, Lun Yao and Yongjin J. Zhou
    Citation: Microbial Cell Factories 2022 21:182
  9. Worldwide, an estimated 70.7 billion broilers were produced in 2020. With the reduction in use of prophylactic antibiotics as a result of consumer pressure and regulatory oversight alternative approaches, such...

    Authors: Alexander A. Smith, Ricardo Corona-Torres, Rachel E. Hewitt, Mark P. Stevens and Andrew J. Grant
    Citation: Microbial Cell Factories 2022 21:181
  10. Komagataella phaffii is a commonly used alternative host for manufacturing therapeutic proteins, in part because of its ability to secrete recombinant proteins into the extracellular space. Incorrect processing o...

    Authors: Neil C. Dalvie, Christopher A. Naranjo, Sergio A. Rodriguez-Aponte, Ryan S. Johnston and J. Christopher Love
    Citation: Microbial Cell Factories 2022 21:180
  11. d-Arabitol, a five-carbon sugar alcohol, represents a main target of microbial biorefineries aiming to valorize cheap substrates. The yeast Wickerhamomyces anomalus WC 1501 is known to produce arabitol in a glyce...

    Authors: Stefano Raimondi, Giorgia Foca, Alessandro Ulrici, Lorenza Destro, Alan Leonardi, Raissa Buzzi, Francesco Candeliere, Maddalena Rossi and Alberto Amaretti
    Citation: Microbial Cell Factories 2022 21:179
  12. Electro-fermentation (EF) is an emerging tool for bioprocess intensification. Benefits are especially expected for bioprocesses in which the cells are enabled to exchange electrons with electrode surfaces dire...

    Authors: Philipp Arbter, Niklas Widderich, Tyll Utesch, Yaeseong Hong and An-Ping Zeng
    Citation: Microbial Cell Factories 2022 21:178
  13. N-glycosylation is one of the most important post-translational modifications. Many studies have shown that N-glycosylation has a significant effect on the secretion level of heterologous glycoproteins in yeas...

    Authors: Nan Wang, Caifeng Yang, Huakang Peng, Wenfang Guo, Mengqi Wang, Gangqiang Li and Dehu Liu
    Citation: Microbial Cell Factories 2022 21:177
  14. The regioselective hydroxylation of phenolic compounds, especially flavonoids, is still a bottleneck of classical organic chemistry that could be solved using enzymes with high activity and specificity. Yeast Rho...

    Authors: Kinga Dulak, Sandra Sordon, Agata Matera, Bartosz Kozak, Ewa Huszcza and Jarosław Popłoński
    Citation: Microbial Cell Factories 2022 21:175
  15. Saccharomyces cerevisiae is often used as a cell factory for the production of S-adenosyl-l-methionine (SAM) for diverse pharmaceutical applications. However, SAM production by S. cerevisiae is negatively influe...

    Authors: Hailong Chen, Xiaoqin Chai, Yan Wang, Jing Liu, Guohai Zhou, Pinghe Wei, Yuhe Song and Lingman Ma
    Citation: Microbial Cell Factories 2022 21:174
  16. Bacillus subtilis, an important industrial microorganism, is commonly used in the production of industrial enzymes. Genome modification is often necessary to improve the production performance of cell. The dual-p...

    Authors: Yu Zou, Lu Qiu, Aowen Xie, Wenyuan Han, Shangbo Zhang, Jinshan Li, Shumiao Zhao, Yingjun Li, Yunxiang Liang and Yongmei Hu
    Citation: Microbial Cell Factories 2022 21:173
  17. Fungal perylenequinones (PQs) are a class of photoactivated polyketide mycotoxins produced by plant-associated fungi. Hypocrellins, the effective anticancer photodynamic therapy (PDT) agents are main bioactive...

    Authors: Rui Xu, Xin Ping Li, Xiang Zhang, Wen Hao Shen, Chun Yan Min and Jian Wen Wang
    Citation: Microbial Cell Factories 2022 21:172
  18. Salmonella is a common foodborne pathogen, which can cause intestinal diseases. In the last decades, the overuse of antibiotics has led to a pandemic of drug-resistant bacterial infections. To tackle the burden ...

    Authors: Shuhang Zhang, Yan Chang, Qing Zhang, Yingbo Yuan, Qingsheng Qi and Xuemei Lu
    Citation: Microbial Cell Factories 2022 21:171
  19. Escherichia coli is one of the most important hosts for production of recombinant proteins in biopharmaceutical industry. However, when selecting a suitable production strain, it is often not considered that a lo...

    Authors: Florian Mayer, Monika Cserjan-Puschmann, Benedikt Haslinger, Anton Shpylovyi, Thomas Dalik, Christian Sam, Rainer Hahn and Gerald Striedner
    Citation: Microbial Cell Factories 2022 21:170
  20. Cordyceps militaris is a traditional medicinal fungus contains a variety of functional ingredients and has been developed as an important mushroom food recently. Ergothioneine, one of the antioxidative compounds...

    Authors: Bai-Xiong Chen, Ling-Na Xue, Tao Wei, Zhi-Wei Ye, Xue-Hai Li, Li-Qiong Guo and Jun-Fang Lin
    Citation: Microbial Cell Factories 2022 21:169
  21. Isopropanol is widely used as a biofuel and a disinfectant. Chemical preparation of isopropanol destroys the environment, which makes biological preparation of isopropanol necessary. Previous studies focused o...

    Authors: Xiaoyu Shi, Hyeon Min Park, Minhye Kim, Myeong-Eun Lee, Wu-Young Jeong, Joonhee Chang, Byeong-Hyeon Cho and Sung Ok Han
    Citation: Microbial Cell Factories 2022 21:168
  22. Escherichia coli (E. coli) is a promising host for production of recombinant proteins (including antibodies and antibody fragments) that don’t require complex post-translational modifications such as glycosylatio...

    Authors: Tomasz K. Baginski, Karthik Veeravalli, Rebekah McKenna, Christopher Williams, Katherine Wong, Christina Tsai, Daniel Hewitt, Karthik Mani and Michael W. Laird
    Citation: Microbial Cell Factories 2022 21:167
  23. Confronted with the exhaustion of the earth’s fossil fuel reservoirs, bio-based process to produce renewable energy is receiving significant interest. Hydrogen is considered as an attractive energy carrier tha...

    Authors: Yujin Cao, Hui Liu, Wei Liu, Jing Guo and Mo Xian
    Citation: Microbial Cell Factories 2022 21:166
  24. Secondary metabolites have played a key role as starting points for drug development programs due to their often unique features compared with synthetically derived molecules. However, limitations related to t...

    Authors: Lillibeth Chaverra-Muñoz, Theresa Briem and Stephan Hüttel
    Citation: Microbial Cell Factories 2022 21:165
  25. Native-like secondary structures and biological activity have been described for proteins in inclusion bodies (IBs). Tertiary structure analysis, however, is hampered due to the necessity of mild solubilizatio...

    Authors: Rosa Maria Chura-Chambi, Chuck Shaker Farah and Ligia Morganti
    Citation: Microbial Cell Factories 2022 21:164
  26. Microbial derived-surfactants display low eco-toxicity, diverse functionality, high biodegradability, high specificity, and stability under extreme conditions. Sophorolipids are emerging as key biosurfactants ...

    Authors: Achmad Rifky Alfian, Kwanrutai Watchaputi, Chayaphathra Sooklim and Nitnipa Soontorngun
    Citation: Microbial Cell Factories 2022 21:163
  27. Fuel ethanol from lignocellulose could be important source of renewable energy. However, to make the process feasible, more efficient microbial fermentation of pentose sugars, mainly xylose, should be achieved...

    Authors: Marta V. Semkiv, Justyna Ruchala, Aksynia Y. Tsaruk, Anastasiya Z. Zazulya, Roksolana V. Vasylyshyn, Olena V. Dmytruk, MingXing Zuo, Yingqian Kang, Kostyantyn V. Dmytruk and Andriy A. Sibirny
    Citation: Microbial Cell Factories 2022 21:162
  28. Riboflavin is a precursor of FMN and FAD which act as coenzymes of numerous enzymes. Riboflavin is an important biotechnological commodity with annual market sales exceeding nine billion US dollars. It is used...

    Authors: Justyna Ruchala, Yuliia A. Andreieva, Andriy O. Tsyrulnyk, Svitlana M. Sobchuk, Alicja Najdecka, Liu Wen, Yingqian Kang, Olena V. Dmytruk, Kostyantyn V. Dmytruk, Dariya V. Fedorovych and Andriy A. Sibirny
    Citation: Microbial Cell Factories 2022 21:161
  29. Saccharomyces cerevisiae generally consumes glucose to produce ethanol accompanied by the main by-products of glycerol, acetic acid, and lactic acid. The minimization of the formation of by-products in S. cerevis...

    Authors: Peizhou Yang, Shuying Jiang, Shuhua Lu, Suwei Jiang, Shaotong Jiang, Yanhong Deng, Jiuling Lu, Hu Wang and Yong Zhou
    Citation: Microbial Cell Factories 2022 21:160
  30. In recent years, there has been a growing demand for microbial production of trans-4-hydroxy-L-proline (t4Hyp), which is a value-added amino acid and has been widely used in the fields of medicine, food, and cosm...

    Authors: Zhenyu Zhang, Weike Su, Yunyun Bao, Qianqian Huang, Kai Ye, Pengfu Liu and Xiaohe Chu
    Citation: Microbial Cell Factories 2022 21:159
  31. Itaconic acid (IA) is a versatile platform chemical widely used for the synthesis of various polymers and current methods for IA production based on Aspergillus terreus fermentation are limited in terms of proces...

    Authors: Yaqi Wang, Yufei Guo, Wei Cao and Hao Liu
    Citation: Microbial Cell Factories 2022 21:158
  32. Expansion of the genetic code is a frequently employed approach for the modification of recombinant protein properties. It involves reassignment of a codon to another, e.g., unnatural, amino acid and requires ...

    Authors: Nora Tir, Lina Heistinger, Clemens Grünwald-Gruber, Leo A. Jakob, Stephan Dickgiesser, Nicolas Rasche and Diethard Mattanovich
    Citation: Microbial Cell Factories 2022 21:157
  33. The inclusion of biosafety strategies into strain engineering pipelines is crucial for safe-by-design biobased processes. This in turn might enable a more rapid regulatory acceptance of bioengineered organisms in...

    Authors: Enrique Asin-Garcia, Christos Batianis, Yunsong Li, James D. Fawcett, Ivar de Jong and Vitor A. P. Martins dos Santos
    Citation: Microbial Cell Factories 2022 21:156
  34. Superoxide dismutases (SODs, EC are defense proteins that can be used as sweepers to clear reactive oxygen species (ROS). They have been widely studied in the plant. Intensive research demonstrates t...

    Authors: Ludan Hou, Zongqi Liu, Kexing Yan, Lijing Xu, Mingchang Chang and Junlong Meng
    Citation: Microbial Cell Factories 2022 21:155
  35. Sugar hydrolysates from lignocellulosic biomass are majorly composed of glucose and xylose that can be fermented to biofuels. Bacteria, despite having the natural ability to consume xylose are unable to consum...

    Authors: Chandra Dev, Syed Bilal Jilani and Syed Shams Yazdani
    Citation: Microbial Cell Factories 2022 21:154
  36. Glutathione is a valuable tri-peptide that is industrially produced by fermentation using the yeast Saccharomyces cerevisiae, and is widely used in the pharmaceutical, food, and cosmetic industries. It has been r...

    Authors: Jyumpei Kobayashi, Daisuke Sasaki, Kiyotaka Y. Hara, Tomohisa Hasunuma and Akihiko Kondo
    Citation: Microbial Cell Factories 2022 21:153
  37. Scopoletin is a typical example of coumarins, which can be produced in plants. Scopoletin acts as a precursor for pharmaceutical and health care products, and also possesses promising biological properties, in...

    Authors: Bo-Tao He, Zhi-Hua Liu, Bing-Zhi Li and Ying-Jin Yuan
    Citation: Microbial Cell Factories 2022 21:152
  38. The complexity, toxicity and abundance of frying oil waste (FOW) render it difficult to be degraded biologically. The aim of the present work was to valorize FOW and investigate the potential use of the produc...

    Authors: Nora M. Elkenawy and Ola M. Gomaa
    Citation: Microbial Cell Factories 2022 21:151
  39. 2,3-butanediol is an important platform compound which has a wide range of applications, involving in medicine, chemical industry, food and other fields. Especially the optically pure (2R,3R)-2,3-butanediol ca...

    Authors: Mengyun Kou, Zhenzhen Cui, Jing Fu, Wei Dai, Zhiwen Wang and Tao Chen
    Citation: Microbial Cell Factories 2022 21:150
  40. The aromatic compound p-coumaric acid (p-CA) is a secondary metabolite produced by plants. This aromatic acid and derived compounds have positive effects on human health, so there is interest in producing them in...

    Authors: José Ignacio Rodríguez-Ochoa, Juan Carlos Fragoso-Jiménez, Noemí Flores, Luz María Martínez, Francisco Bolivar, Alfredo Martinez and Guillermo Gosset
    Citation: Microbial Cell Factories 2022 21:148
  41. Macrolactins, a type of macrolide antibiotic, are toxic to the producer strains. As such, its level is usually maintained below the lethal concentration during the fermentation process. To improve the producti...

    Authors: Yuman Gan, Meng Bai, Xiao Lin, Kai Liu, Bingyao Huang, Xiaodong Jiang, Yonghong Liu and Chenghai Gao
    Citation: Microbial Cell Factories 2022 21:147
  42. Cyclic dipeptides are an important class of natural products owing to their structural diversity and biological activities. In fungi, the cyclo-ring system is formed through the condensation of two α-amino aci...

    Authors: Jianzhao Qi, Haiyan Han, Dan Sui, Shengnan Tan, Changli Liu, Pengchao Wang, Chunliang Xie, Xuekui Xia, Jin-ming Gao and Chengwei Liu
    Citation: Microbial Cell Factories 2022 21:146
  43. The fungal natural products illudin S and M have been investigated as precursors for the development of semisynthetic anticancer agents such as Irofulven (illudin S derivative) which is currently in phase II c...

    Authors: Lillibeth Chaverra-Muñoz and Stephan Hüttel
    Citation: Microbial Cell Factories 2022 21:145
  44. Filamentous fungi are highly efficient at deconstructing plant biomass by secreting a variety of enzymes, but the complex enzymatic regulation underlying this process is not conserved and remains unclear.

    Authors: Yanwei Xia, Jingfan Wang, Chuanxu Guo, Huanhuan Xu, Wei Wang, Mingzhu Yang, Qirong Shen, Ruifu Zhang and Youzhi Miao
    Citation: Microbial Cell Factories 2022 21:144
  45. 1,5-Diamino-2-hydroxy-pentane (2-OH-PDA), as a new type of aliphatic amino alcohol, has potential applications in the pharmaceutical, chemical, and materials industries. Currently, 2-OH-PDA production has only...

    Authors: Yangyang Li, Alei Zhang, Shewei Hu, Kequan Chen and Pingkai Ouyang
    Citation: Microbial Cell Factories 2022 21:142
  46. There are substantial environmental and health risks associated with the seafood industry's waste of crab shells. In light of these facts, shellfish waste management is critical for environmental protection ag...

    Authors: Soad A. Abdelgalil and Gaber A. Abo-Zaid
    Citation: Microbial Cell Factories 2022 21:141
  47. Poly-γ-glutamic acid (γ-PGA) is a biopolymer and has various applications based on its biocompatibility, non-toxicity, and edibility. Low-molecular-weight (Mw)-γ-PGA has promising applications in agriculture a...

    Authors: Jing Li, Shengbao Chen, Jiaming Fu, Jianchun Xie, Jiansong Ju, Bo Yu and Limin Wang
    Citation: Microbial Cell Factories 2022 21:140

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