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  1. The amyloid-β peptide (Aβ42) is the main component of the inter-neuronal amyloid plaques characteristic of Alzheimer's disease (AD). The mechanism by which Aβ42 and other amyloid peptides assemble into insolub...

    Authors: Anna Villar-Piqué, Alba Espargaró, Raimon Sabaté, Natalia S de Groot and Salvador Ventura
    Citation: Microbial Cell Factories 2012 11:55
  2. Poly(4-hydroxybutyrate) [poly(4HB)] is a strong thermoplastic biomaterial with remarkable mechanical properties, biocompatibility and biodegradability. However, it is generally synthesized when 4-hydroxybutyra...

    Authors: Xiao-Yun Zhou, Xiao-Xi Yuan, Zhen-Yu Shi, De-Chuang Meng, Wen-Jun Jiang, Lin-Ping Wu, Jin-Chun Chen and Guo-Qiang Chen
    Citation: Microbial Cell Factories 2012 11:54
  3. Protein-based therapeutics represent the fastest growing class of compounds in the pharmaceutical industry. This has created an increasing demand for powerful expression systems. Yeast systems are widely used,...

    Authors: Karen De Pourcq, Wouter Vervecken, Isabelle Dewerte, Albena Valevska, Annelies Van Hecke and Nico Callewaert
    Citation: Microbial Cell Factories 2012 11:53
  4. Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug disco...

    Authors: Juana Diez, Javier P Martinez, Jordi Mestres, Florenz Sasse, Ronald Frank and Andreas Meyerhans
    Citation: Microbial Cell Factories 2012 11:52
  5. Conjugated linoleic acid (CLA) has many well-documented beneficial physiological effects. Due to the insufficient natural supply of CLA and low specificity of chemically produced CLA, an effective and isomer-s...

    Authors: Baixi Zhang, Chunchi Rong, Haiqin Chen, Yuanda Song, Hao Zhang and Wei Chen
    Citation: Microbial Cell Factories 2012 11:51
  6. Benzoic acid is one of the most useful aromatic compounds. Despite its versatility and simple structure, benzoic acid production using microbes has not been reported previously. Streptomyces are aerobic, Gram-pos...

    Authors: Shuhei Noda, Eiichi Kitazono, Tsutomu Tanaka, Chiaki Ogino and Akihiko Kondo
    Citation: Microbial Cell Factories 2012 11:49
  7. 2'-Fucosyllactose (2-FL) is a functional oligosaccharide present in human milk which protects against the infection of enteric pathogens. Because 2-FL can be synthesized through the enzymatic fucosylation of l...

    Authors: Won-Heong Lee, Panchalee Pathanibul, Josh Quarterman, Jung-Hyun Jo, Nam Soo Han, Michael J Miller, Yong-Su Jin and Jin-Ho Seo
    Citation: Microbial Cell Factories 2012 11:48
  8. D-phenylglycine aminotransferase (D-PhgAT) of Pseudomonas stutzeri ST-201 catalyzes the reversible stereo-inverting transamination potentially useful in the application for synthesis of D-phenylglycine and D-4-hy...

    Authors: Kanidtha Jariyachawalid, Poramaet Laowanapiban, Vithaya Meevootisom and Suthep Wiyakrutta
    Citation: Microbial Cell Factories 2012 11:47
  9. Glycerol has enhanced its biotechnological importance since it is a byproduct of biodiesel synthesis. A study of Escherichia coli physiology during growth on glycerol was performed combining transcriptional-prote...

    Authors: Karla Martínez-Gómez, Noemí Flores, Héctor M Castañeda, Gabriel Martínez-Batallar, Georgina Hernández-Chávez, Octavio T Ramírez, Guillermo Gosset, Sergio Encarnación and Francisco Bolivar
    Citation: Microbial Cell Factories 2012 11:46
  10. Receptors with a single transmembrane (TM) domain are essential for the signal transduction across the cell membrane. NMR spectroscopy is a powerful tool to study structure of the single TM domain. The express...

    Authors: Qingxin Li, Angela Shuyi Chen, Shovanlal Gayen and CongBao Kang
    Citation: Microbial Cell Factories 2012 11:45
  11. Block polyhydroxyalkanoates (PHA) were reported to be resistant against polymer aging that negatively affects polymer properties. Recently, more and more attempts have been directed to make PHA block copolymer...

    Authors: Lakshmi Tripathi, Lin-Ping Wu, Jinchun Chen and Guo-Qiang Chen
    Citation: Microbial Cell Factories 2012 11:44
  12. In the last years, the biotechnological production of platform chemicals for fuel components has become a major focus of interest. Although ligno-cellulosic material is considered as suitable feedstock, the al...

    Authors: Tobias Klement, Sofia Milker, Gernot Jäger, Philipp M Grande, Pablo Domínguez de María and Jochen Büchs
    Citation: Microbial Cell Factories 2012 11:43
  13. Caffeic acid (3,4-dihydroxycinnamic acid) is a natural phenolic compound derived from the plant phenylpropanoid pathway. Caffeic acid and its phenethyl ester (CAPE) have attracted increasing attention for thei...

    Authors: Yuheng Lin and Yajun Yan
    Citation: Microbial Cell Factories 2012 11:42

    The Erratum to this article has been published in Microbial Cell Factories 2015 14:110

  14. As an alternative for economic biodiesel production, the microbial production of extracellular fatty acid from renewable resources is receiving more concerns recently, since the separation of fatty acid from m...

    Authors: Hui Liu, Chao Yu, Dexin Feng, Tao Cheng, Xin Meng, Wei Liu, Huibin Zou and Mo Xian
    Citation: Microbial Cell Factories 2012 11:41
  15. During the bread-making process, industrial baker's yeast, mostly Saccharomyces cerevisiae, is exposed to baking-associated stresses, such as air-drying and freeze-thaw stress. These baking-associated stresses ex...

    Authors: Yu Sasano, Yutaka Haitani, Keisuke Hashida, Iwao Ohtsu, Jun Shima and Hiroshi Takagi
    Citation: Microbial Cell Factories 2012 11:40
  16. The recalcitrant nature of hemicellulosic materials and the high cost in depolymerization are the primary obstacles preventing the use of xylan as feedstock for fuel and chemical production. Consolidated biopr...

    Authors: Zongbao Zheng, Tao Chen, Meina Zhao, Zhiwen Wang and Xueming Zhao
    Citation: Microbial Cell Factories 2012 11:37
  17. Saccharomyces cerevisiae CEN.PK 113-7D is widely used for metabolic engineering and systems biology research in industry and academia. We sequenced, assembled, annotated and analyzed its genome. Single-nucleotide...

    Authors: Jurgen F Nijkamp, Marcel van den Broek, Erwin Datema, Stefan de Kok, Lizanne Bosman, Marijke A Luttik, Pascale Daran-Lapujade, Wanwipa Vongsangnak, Jens Nielsen, Wilbert HM Heijne, Paul Klaassen, Chris J Paddon, Darren Platt, Peter Kötter, Roeland C van Ham, Marcel JT Reinders…
    Citation: Microbial Cell Factories 2012 11:36
  18. Several species belonging to the ecological group of white-rot basidiomycetes are able to bring about the remediation of matrices contaminated by a large variety of anthropic organic pollutants. Among them, po...

    Authors: Ermanno Federici, Mariangela Giubilei, Guglielmo Santi, Giulio Zanaroli, Andrea Negroni, Fabio Fava, Maurizio Petruccioli and Alessandro D'Annibale
    Citation: Microbial Cell Factories 2012 11:35
  19. Pseudomonas putida KT2442 is a natural producer of polyhydroxyalkanoates (PHAs), which can substitute petroleum-based non-renewable plastics and form the basis for the production of tailor-made biopolymers. Howev...

    Authors: Ignacio Poblete-Castro, Isabel F Escapa, Christian Jäger, Jacek Puchalka, Carolyn Ming Chi Lam, Dietmar Schomburg, María Auxiliadora Prieto and Vítor AP Martins dos Santos
    Citation: Microbial Cell Factories 2012 11:34
  20. Pyrethroid pesticides are broad-spectrum pest control agents in agricultural production. Both agricultural and residential usage is continuing to grow, leading to the development of insecticide resistance in t...

    Authors: Xinjiong Fan, Xiaolong Liu, Rui Huang and Yuhuan Liu
    Citation: Microbial Cell Factories 2012 11:33
  21. The molecular mechanisms altered by the traditional mutation and screening approach during the improvement of antibiotic-producing microorganisms are still poorly understood although this information is essent...

    Authors: Clelia Peano, Adelfia Talà, Giorgio Corti, Daniela Pasanisi, Miriana Durante, Giovanni Mita, Silvio Bicciato, Gianluca De Bellis and Pietro Alifano
    Citation: Microbial Cell Factories 2012 11:32
  22. L-tryptophan is an aromatic amino acid widely used in the food, chemical and pharmaceutical industries. In Escherichia coli, L-tryptophan is synthesized from phosphoenolpyruvate and erythrose 4-phosphate by enzym...

    Authors: Pengfei Gu, Fan Yang, Junhua Kang, Qian Wang and Qingsheng Qi
    Citation: Microbial Cell Factories 2012 11:30
  23. The lipase subfamilies I.1 and I.2 show more than 33% homology in the amino acid sequences and most members share another common property that their genes are clustered with the secondary genes whose protein p...

    Authors: ThiDinh Quyen, ChiHai Vu and GiangThi Thu Le
    Citation: Microbial Cell Factories 2012 11:29
  24. Lunasin is a chemopreventive peptide produced in a number of plant species. It comprises a helical region with homology to a region of chromatin binding proteins, an Arg-Gly-Asp cell adhesion motif and eight a...

    Authors: Stuart Kyle, Kier AR James and Michael J McPherson
    Citation: Microbial Cell Factories 2012 11:28
  25. Fermentation of xylose, the major component in hemicellulose, is essential for economic conversion of lignocellulosic biomass to fuels and chemicals. The yeast Scheffersomyces stipitis (formerly known as Pichia s...

    Authors: Balaji Balagurunathan, Sudhakar Jonnalagadda, Lily Tan and Rajagopalan Srinivasan
    Citation: Microbial Cell Factories 2012 11:27
  26. Little is known about the structure and regulation of fungal α-L-rhamnosidase genes despite increasing interest in the biotechnological potential of the enzymes that they encode. Whilst the paradigmatic filame...

    Authors: Juan A Tamayo-Ramos, Michel Flipphi, Ester Pardo, Paloma Manzanares and Margarita Orejas
    Citation: Microbial Cell Factories 2012 11:26
  27. Recently, the increased demand of energy has strongly stimulated the research on the conversion of lignocellulosic biomass into reducing sugars for the subsequent production, and β-glucosidases have been the f...

    Authors: Dongyang Liu, Ruifu Zhang, Xingming Yang, Zhenhua Zhang, Song Song, Youzhi Miao and Qirong Shen
    Citation: Microbial Cell Factories 2012 11:25
  28. Sodalis glossinidius, a gram-negative bacterial endosymbiont of the tsetse fly, has been proposed as a potential in vivo drug delivery vehicle to control trypanosome parasite development in the fly, an approach k...

    Authors: Linda De Vooght, Guy Caljon, Benoît Stijlemans, Patrick De Baetselier, Marc Coosemans and Jan Van Den Abbeele
    Citation: Microbial Cell Factories 2012 11:23
  29. The methylotrophic yeast Pichia pastoris has become an important host organism for recombinant protein production and is able to use methanol as a sole carbon source. The methanol utilization pathway describes al...

    Authors: Florian W Krainer, Christian Dietzsch, Tanja Hajek, Christoph Herwig, Oliver Spadiut and Anton Glieder
    Citation: Microbial Cell Factories 2012 11:22
  30. Trichoderma reesei is the preferred organism for producing industrial cellulases. However, a more efficient heterologous expression system for enzymes from different organism is needed to further improve its cell...

    Authors: Gen Zou, Shaohua Shi, Yanping Jiang, Joost van den Brink, Ronald P de Vries, Ling Chen, Jun Zhang, Liang Ma, Chengshu Wang and Zhihua Zhou
    Citation: Microbial Cell Factories 2012 11:21
  31. For metabolic engineering, many rate-limiting steps may exist in the pathways of accumulating the target metabolites. Increasing copy number of the desired genes in these pathways is a general method to solve ...

    Authors: Mingji Li, Junshu Wang, Yanping Geng, Yikui Li, Qian Wang, Quanfeng Liang and Qingsheng Qi
    Citation: Microbial Cell Factories 2012 11:19
  32. The use of a multistarter fermentation process with Saccharomyces cerevisiae and non-Saccharomyces wine yeasts has been proposed to simulate natural must fermentation and to confer greater complexity and specific...

    Authors: Vesna Milanovic, Maurizio Ciani, Lucia Oro and Francesca Comitini
    Citation: Microbial Cell Factories 2012 11:18
  33. The ability to synthesize exopolysaccharides (EPS) is widespread among microorganisms, and microbial EPS play important roles in biofilm formation, pathogen persistence, and applications in the food and medica...

    Authors: Anne M Ruffing and Rachel Ruizhen Chen
    Citation: Microbial Cell Factories 2012 11:17
  34. The recycling of the organic matter is a crucial function in any environment, especially in oligotrophic environments such as Acid Mine Drainages (AMDs). Polymer-degrading bacteria might play an important role...

    Authors: François Delavat, Vincent Phalip, Anne Forster, Marie-Claire Lett and Didier Lièvremont
    Citation: Microbial Cell Factories 2012 11:16
  35. Although the occurrence, biosynthesis and possible functions of glycoproteins are increasingly documented for pathogens, glycoproteins are not yet widely described in probiotic bacteria. Nevertheless, knowledg...

    Authors: Sarah Lebeer, Ingmar JJ Claes, Crina IA Balog, Geert Schoofs, Tine LA Verhoeven, Kris Nys, Ingemar von Ossowski, Willem M de Vos, Hanne LP Tytgat, Patrizia Agostinis, Airi Palva, Els JM Van Damme, André M Deelder, Sigrid CJ De Keersmaecker, Manfred Wuhrer and Jos Vanderleyden
    Citation: Microbial Cell Factories 2012 11:15
  36. Immune responses directed towards surface polysaccharides conjugated to proteins are effective in preventing colonization and infection of bacterial pathogens. Presently, the production of these conjugate vacc...

    Authors: Jeremy A Iwashkiw, Messele A Fentabil, Amirreza Faridmoayer, Dominic C Mills, Mark Peppler, Cecilia Czibener, Andres E Ciocchini, Diego J Comerci, Juan E Ugalde and Mario F Feldman
    Citation: Microbial Cell Factories 2012 11:13
  37. The Antarctic fungus Lecanicillium muscarium CCFEE 5003 is one of the most powerful chitinolytic organisms. It can produce high level of chitinolytic enzymes in a wide range of temperatures (5-30°C). Chitinolytic...

    Authors: Massimiliano Fenice, Paolo Barghini, Laura Selbmann and Federico Federici
    Citation: Microbial Cell Factories 2012 11:12
  38. Molecular mechanisms generating genetic variation provide the basis for evolution and long-term survival of a population in a changing environment. In stable, laboratory conditions, the variation-generating me...

    Authors: Bálint Csörgő, Tamás Fehér, Edit Tímár, Frederick R Blattner and György Pósfai
    Citation: Microbial Cell Factories 2012 11:11
  39. For fermentation process and strain improvement, where one wants to screen a large number of conditions and strains, robust and scalable high-throughput cultivation systems are crucial. Often, the time lag bet...

    Authors: Sujata Vijay Sohoni, Prashant Madhusudan Bapat and Anna Eliasson Lantz
    Citation: Microbial Cell Factories 2012 11:9
  40. Extracellular expression of proteins has an absolute advantage in a large-scale industrial production. In our previous study, Thermobifida fusca cutinase, an enzyme mainly utilized in textile industry, was expres...

    Authors: Lingqia Su, Sheng Chen, Li Yi, Ronald W Woodard, Jian Chen and Jing Wu
    Citation: Microbial Cell Factories 2012 11:8
  41. Enzymatic NADH or NADPH-dependent reduction is a widely applied approach for the synthesis of optically active organic compounds. The overall biocatalytic conversion usually involves in situ regeneration of the e...

    Authors: Katharina Mädje, Katharina Schmölzer, Bernd Nidetzky and Regina Kratzer
    Citation: Microbial Cell Factories 2012 11:7
  42. The secretion of heterologous animal proteins in filamentous fungi is usually limited by bottlenecks in the vesicle-mediated secretory pathway.

    Authors: Katarina Kosalková, Carlos García-Estrada, Carlos Barreiro, Martha G Flórez, Mohammad S Jami, Miguel A Paniagua and Juan F Martín
    Citation: Microbial Cell Factories 2012 11:5

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