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  1. Providing sufficient and usable energy for the cell factory has long been a heated issue in biosynthesis as solar energy has never been rooted out from the strategy for improvement, and turning Escherichia coli (...

    Authors: Chao-Yu Lee, Kai-Wen Chen, Chih-Lu Chiang, Hsuan-Yu Kao, Hao-Cheng Yu, Hsiao-Ching Lee and Wen-Liang Chen
    Citation: Microbial Cell Factories 2023 22:207
  2. Coenzyme Q10 (CoQ10) is crucial for human beings, especially in the fields of biology and medicine. The aim of this experiment was to investigate the conditions for increasing CoQ10 production. At present, microb...

    Authors: Yujun Xiao, Yi Zheng, Yong Zhou, Chaofan Yu and Ting-E Ye
    Citation: Microbial Cell Factories 2023 22:206
  3. Edible mushrooms are delicious in flavour and rich in high-quality protein and amino acids required by humans. A transcription factor, general control nonderepressible 4 (GCN4), can regulate the expression of ...

    Authors: Lingdan Lian, Jinjin Qiao, Xiaoyu Guo, Zhenzhen Xing, Ang Ren, Mingwen Zhao and Jing Zhu
    Citation: Microbial Cell Factories 2023 22:205
  4. “ATP wasting” has been observed in 13C metabolic flux analyses of Saccharomyces cerevisiae, a yeast strain commonly used to produce ethanol. Some strains of S. cerevisiae, such as the sake strain Kyokai 7, consum...

    Authors: Futa Yatabe, Taisuke Seike, Nobuyuki Okahashi, Jun Ishii and Fumio Matsuda
    Citation: Microbial Cell Factories 2023 22:204
  5. Bacillus subtilis is one of the workhorses in industrial biotechnology and well known for its secretion potential. Efficient secretion of recombinant proteins still requires extensive optimization campaigns and s...

    Authors: Patrick Lenz, Patrick J. Bakkes, Carolin Müller, Marzena Malek, Roland Freudl, Marco Oldiges, Thomas Drepper, Karl-Erich Jaeger and Andreas Knapp
    Citation: Microbial Cell Factories 2023 22:203
  6. The application of exopolysaccharide-producing bacteria (EPS) in dual chamber microbial fuel cells (DCMFC) is critical which can minimize the chemical oxygen demand (COD) of molasses with bioelectricity produc...

    Authors: Ebtehag A. E. Sakr, Dena Z. Khater, Zeinab M. H. Kheiralla and Kamel M. El‑khatib
    Citation: Microbial Cell Factories 2023 22:202
  7. Xylitol has a wide range of applications in the pharmaceuticals, cosmetic, food and beverage industry. Microbial xylitol production reduces the risk of contamination and is considered as environment friendly a...

    Authors: Anup Kumar Singh, Farha Deeba, Mohit Kumar, Sonam Kumari, Shahid Ali Wani, Tanushree Paul and Naseem A. Gaur
    Citation: Microbial Cell Factories 2023 22:201
  8. Bacillus subtilis has been established as model microorganism for fundamental research in the laboratory on protein production/secretion and sporulation and as model bacterium for controlling spoilage in the food...

    Authors: Taichi Chen, Stanley Brul and Jeroen Hugenholtz
    Citation: Microbial Cell Factories 2023 22:200
  9. Long-chain polyunsaturated fatty acids (LC-PUFAs), such as docosahexaenoic acid (DHA), are essential for human health and have been widely used in the food and pharmaceutical industries. However, the limited a...

    Authors: Demian Dietrich, Sofija Jovanovic-Gasovic, Peng Cao, Michael Kohlstedt and Christoph Wittmann
    Citation: Microbial Cell Factories 2023 22:199
  10. Methanol, synthesized from CO2, is a potentially sustainable one-carbon (C1) resource for biomanufacturing. The use of methanol as a feedstock to produce single cell protein (SCP) has been investigated for decade...

    Authors: Jiao Meng, Shufan Liu, Le Gao, Kai Hong, Shuguang Liu and Xin Wu
    Citation: Microbial Cell Factories 2023 22:198
  11. Ovarian cancer is one of the most frequent and deadly gynaecological cancers, often resistant to platinum-based chemotherapy, the current standard of care. Halophilic microorganisms have been shown to produce ...

    Authors: Magdalena Kowalewicz-Kulbat, Krzysztof T. Krawczyk, Izabela Szulc-Kielbik, Sebastian Rykowski, Marta Denel-Bobrowska, Agnieszka B. Olejniczak, Camille Locht and Magdalena Klink
    Citation: Microbial Cell Factories 2023 22:197
  12. With concerns about depletion of fossil fuel and environmental pollution, synthesis of biofuels such as isobutanol from low-cost substrate by microbial cell factories has attracted more and more attention. As ...

    Authors: Pengfei Gu, Shuo Zhao, Hao Niu, Chengwei Li, Shuixing Jiang, Hao Zhou and Qiang Li
    Citation: Microbial Cell Factories 2023 22:196
  13. In this study, the effect of static magnetic fields (SMFs) on improving the performance of activated sludge process to enhance the higher rate of microbial growth biomass and improve sludge settling characteri...

    Authors: Ghorban Asgari, Abdolmotaleb Seid-Mohammadi, Reza Shokoohi, Mohammad Reza Samarghandi, Glen T. Daigger, Behrooz Malekolkalami and Ramin Khoshniyat
    Citation: Microbial Cell Factories 2023 22:195
  14. Neutralizing antibody plays a key role in protecting hosts from invasive pathogens and their virulent components. Current high-throughput assays for antibody screening are based on binding activities. However,...

    Authors: Ying Sun, Yongrong Zhang, Hua Yu, Ashley Saint Fleur, Di Yu, Zhiyong Yang and Hanping Feng
    Citation: Microbial Cell Factories 2023 22:194
  15. Natural and anthropogenic activities, such as weathering of rocks and industrial processes, result in the release of toxic oxyanions such as selenium (Se) and tellurium (Te) into the environment. Due to the hi...

    Authors: Firooz Hosseini, Maryam Hadian, Elham Lashani and Hamid Moghimi
    Citation: Microbial Cell Factories 2023 22:193
  16. Microbial degradation of synthetic dyes is considered a promising green dye detoxification, cost-effective and eco-friendly approach. A detailed study on the decolorization and degradation of malachite green d...

    Authors: Magda A. El-Bendary, Mariam E. Fawzy, Mohamed Abdelraof, Mervat El-Sedik and Mousa A. Allam
    Citation: Microbial Cell Factories 2023 22:192
  17. Fatty acid (FA) is an important platform compound for the further synthesis of high‐value biofuels and oleochemicals, but chemical synthesis of FA has many limitations. One way to meet the future demand for FA...

    Authors: Jin Liu, Mandlaa, Jia Wang, Ziyu Sun and Zhongjun Chen
    Citation: Microbial Cell Factories 2023 22:191
  18. Hydrogen is a promising source of alternative energy. Fermentative production is more feasible because of its high hydrogen generation rate, simple operating conditions, and utilization of various organic wast...

    Authors: Eman S. E. Aldaby, Aya H. A. Mahmoud, Haitham M. El-Bery, Maysa M. Ali, Ahmed A. Shoreit and Asmaa M. M. Mawad
    Citation: Microbial Cell Factories 2023 22:190
  19. Plastics are an indispensable part of our daily life. However, mismanagement at their end-of-life results in severe environmental consequences. The microbial conversion of these polymers into new value-added p...

    Authors: Tom Delmulle, Stijn Bovijn, Sari Deketelaere, Martijn Castelein, Tom Erauw, Matthias D’hooghe and Wim K. Soetaert
    Citation: Microbial Cell Factories 2023 22:188
  20. Enzymes from thermophiles are of great interest for research and bioengineering due to their stability and efficiency. Thermophilic expression hosts such as Thermus thermophilus [T. thermophilus] can overcome spe...

    Authors: Lennart Kirchner, Volker Müller and Beate Averhoff
    Citation: Microbial Cell Factories 2023 22:187
  21. The budding yeast Saccharomyces cerevisiae (S. cerevisiae) is a well-established model system for studying protein aggregation due to the conservation of essential cellular structures and pathways found across eu...

    Authors: Javier Garcia-Pardo, Aleksandra E. Badaczewska-Dawid, Carlos Pintado-Grima, Valentín Iglesias, Aleksander Kuriata, Sebastian Kmiecik and Salvador Ventura
    Citation: Microbial Cell Factories 2023 22:186
  22. In the recombinant protein market with broad economic value, the rapid development of synthetic biology has made it necessary to construct an efficient exocrine expression system for the different heterologous...

    Authors: Siqian Yu, Ge Zhang, Qi Liu, Yingping Zhuang, Zongjie Dai and Jianye Xia
    Citation: Microbial Cell Factories 2023 22:185
  23. Bioplastics are attracting considerable attention, owing to the increase in non-degradable waste. Using microorganisms to degrade bioplastics is a promising strategy for reducing non-degradable plastic waste. ...

    Authors: Su Hyun Kim, Nara Shin, Suk Jin Oh, Jeong Hyeon Hwang, Hyun Jin Kim, Shashi Kant Bhatia, Jeonghee Yun, Jae-Seok Kim and Yung-Hun Yang
    Citation: Microbial Cell Factories 2023 22:184
  24. Microbial fuel cell (MFC) is a bio-electrical energy generator that uses respiring microbes to transform organic matter present in sludge into electrical energy. The primary goal of this work was to introduce ...

    Authors: Amal S. Othman, Nashwa A. Ahmed, Mona S. Elneklawi, Mansour M. Hassan and Mahmoud Abd El-Mongy
    Citation: Microbial Cell Factories 2023 22:183
  25. In the post-genomic era, the demand for faster and more efficient protein production has increased, both in public laboratories and industry. In addition, with the expansion of protein sequences in databases, ...

    Authors: Manman Sun, Alex Xiong Gao, Xiuxia Liu, Yankun Yang, Rodrigo Ledesma-Amaro and Zhonghu Bai
    Citation: Microbial Cell Factories 2023 22:182
  26. The advantages of γ-cyclodextrin (γ-CD) include its high solubility, ability to form inclusion complexes with various poorly water-soluble molecules, and favorable toxicological profile; thus, γ-CD is an attra...

    Authors: Menglu Duan, Yan Wang, Dan Tan, Guowu Yang, Yuan Deng, Ganqiao Ran and Jiao Li
    Citation: Microbial Cell Factories 2023 22:181
  27. Saccharomyces cerevisiae has been used in the biosynthesis of acid products such as organic acids owing to its acid tolerance. Improving the acid tolerance of S. cerevisiae is beneficial for expanding its applica...

    Authors: Xueqin Lv, Ke Jin, Yu Yi, Lingang Song, Xiang Xiu, Yanfeng Liu, Jianghua Li, Guocheng Du, Jian Chen and Long Liu
    Citation: Microbial Cell Factories 2023 22:180
  28. Alginate oligosaccharides (AOs) are the degradation products of alginate, a natural polysaccharide abundant in brown algae. AOs generated by enzymatic hydrolysis have diverse bioactivities and show broad appli...

    Authors: Xiao-Hui Sun, Xiu-Lan Chen, Xiao-Fei Wang, Xin-Ru Zhang, Xiao-Meng Sun, Mei-Ling Sun, Xi-Ying Zhang, Yu-Zhong Zhang, Yu-Qiang Zhang and Fei Xu
    Citation: Microbial Cell Factories 2023 22:179
  29. γ-aminobutyric acid (GABA) is a bioactive compound produced by lactic acid bacteria (LAB). The diversity of GABA production in the Lactococcus genus is poorly understood. Genotypic and phenotypic approaches were ...

    Authors: Valérie Laroute, Nathalie Aubry, Marjorie Audonnet, Muriel Mercier-Bonin, Marie-Line Daveran-Mingot and Muriel Cocaign-Bousquet
    Citation: Microbial Cell Factories 2023 22:178
  30. Avian pathogenic Escherichia coli (APEC) is the major pathogen causing important avian diseases in poultry. As an important subtype of extraintestinal pathogenic E. coli, APEC has zoonotic potential and is consid...

    Authors: Zhongxing Wang, Dongyu Zhu, Yuting Zhang, Fufang Xia, Jiaying Zhu, Jianjun Dai and Xiangkai Zhuge
    Citation: Microbial Cell Factories 2023 22:177
  31. Bioemulsifiers are natural or microbial-based products with the ability to emulsify hydrophobic compounds in water. These compounds are biodegradable, eco-friendly, and find applications in various industries.

    Authors: Yasmina A. Elsaygh, Mona K. Gouda, Yasser Elbahloul, Moustafa Abdel Hakim and Nancy M. El Halfawy
    Citation: Microbial Cell Factories 2023 22:176
  32. Adaptive laboratory evolution (ALE) is known as a powerful tool for untargeted engineering of microbial strains and genomics research. It is particularly well suited for the adaptation of microorganisms to new...

    Authors: Lars Halle, Niels Hollmann, Niklas Tenhaef, Lea Mbengi, Christiane Glitz, Wolfgang Wiechert, Tino Polen, Meike Baumgart, Michael Bott and Stephan Noack
    Citation: Microbial Cell Factories 2023 22:175
  33. Surface display co-opts yeast’s innate ability to embellish its cell wall with mannoproteins, thus converting the yeast’s outer surface into a growing and self-sustaining catalyst. However, the efficient toolb...

    Authors: Tea Martinić Cezar, Mateja Lozančić, Ana Novačić, Ana Matičević, Dominik Matijević, Béatrice Vallée, Vladimir Mrša, Renata Teparić and Bojan Žunar
    Citation: Microbial Cell Factories 2023 22:174
  34. Marine macroalgae have gained interest recently, mostly due to their bioactive components. Polycladia crinita is an example of marine macroalgae from the Phaeophyceae class, also known as brown algae. They are ch...

    Authors: Alanood S. Almurshedi, Thanaa A. El-Masry, Hend Selim, Mostafa M. El-Sheekh, Mofida E. M. Makhlof, Basmah N. Aldosari, Iman M. Alfagih, Bushra T. AlQuadeib, Salma S. Almarshidy and Maisra M. El-Bouseary
    Citation: Microbial Cell Factories 2023 22:173
  35. Pyruvate is a widely used value-added chemical which also serves as a hub of various metabolic pathways. The fastest-growing bacterium Vibrio natriegens is a promising chassis for synthetic biology applications w...

    Authors: Fengli Wu, Shucai Wang, Yanfeng Peng, Yufeng Guo and Qinhong Wang
    Citation: Microbial Cell Factories 2023 22:172
  36. Polyhydroxyalkanoate (PHA) is one of the most promising materials for replacing petroleum-based plastics, and it can be produced from various renewable biomass sources. In this study, PHA production was conduc...

    Authors: Yerin Park, Jong-Min Jeon, Jea-Kyung Park, Yung-Hun Yang, Shin Sik Choi and Jeong-Jun Yoon
    Citation: Microbial Cell Factories 2023 22:171
  37. Oro-gastrointestinal stress in the digestive tract is the main stress to which orally administered probiotics are exposed. The regulation of oro-gastrointestinal transit (OGT) stress on the adhesion and surviv...

    Authors: Dawei Chen, Chunmeng Chen, Congcong Guo, Hui Zhang, Yating Liang, Yue Cheng, Hengxian Qu, Yunchao Wa, Chenchen Zhang, Chengran Guan, Jianya Qian and Ruixia Gu
    Citation: Microbial Cell Factories 2023 22:170
  38. Endophytes, especially those isolated from herbal plants, may act as a reservoir of a variety of secondary metabolites exhibiting biological activity. Some endophytes express the ability to produce the same bi...

    Authors: Olga Marchut-Mikołajczyk, Magdalena Chlebicz, Monika Kawecka, Agnieszka Michalak, Filip Prucnal, Maciej Nielipinski, Jakub Filipek, Michalina Jankowska, Zofia Perek, Piotr Drożdżyński, Natalia Rutkowska and Anna Otlewska
    Citation: Microbial Cell Factories 2023 22:169
  39. Microbial production of aromatic chemicals is an attractive method for obtaining high-performance materials from biomass resources. A non-proteinogenic amino acid, 4-amino-3-hydroxybenzoic acid (4,3-AHBA), is ...

    Authors: Kyoshiro Nonaka, Tatsuya Osamura and Fumikazu Takahashi
    Citation: Microbial Cell Factories 2023 22:168
  40. Pyocyanin is a secondary metabolite secreted by P. aeruginosa. It is a redox-active blue/green phenazine pigment that has various beneficial applications. The present study aims at screening the production of pyo...

    Authors: Heba Shouman, Heba Shehta Said, Hany I. Kenawy and Ramadan Hassan
    Citation: Microbial Cell Factories 2023 22:166
  41. 3-Hydroxybutanone (Acetoin, AC) and 2,3-butanediol (BD) are two essential four-carbon platform compounds with numerous pharmaceutical and chemical synthesis applications. AC and BD have two and three stereoiso...

    Authors: Yuchen Li, Xiangying Zhao, Mingjing Yao, Wenli Yang, Yanlei Han, Liping Liu, Jiaxiang Zhang and Jianjun Liu
    Citation: Microbial Cell Factories 2023 22:165
  42. Recently, researchers have focused on the search for alternatives to conventional antibiotics. Antimicrobial peptides are small bioactive peptides that regulate immune activation and have antibacterial activit...

    Authors: Chunming Dong, Lijun Xu, Weitao Lu, Mengru Li, Rui Zhang, Yanyan Sun, Jian Liu and Xinlei Chu
    Citation: Microbial Cell Factories 2023 22:164
  43. Poly-β-hydroxybutyrate (PHB), produced by a variety of microbial organisms, is a good substitute for petrochemically derived plastics due to its excellent properties such as biocompatibility and biodegradabili...

    Authors: Yue Ming, Guoqiang Li, Zhuangzhuang Shi, Xin Zhao, Yufei Zhao, Ge Gao, Ting Ma and Mengmeng Wu
    Citation: Microbial Cell Factories 2023 22:162
  44. The non-conventional yeast Rhodotorula toruloides is an emerging host organism in biotechnology by merit of its natural capacity to accumulate high levels of carotenoids and intracellular storage lipids from a va...

    Authors: Daniel P. Brink, Friederike Mierke, Joakim Norbeck, Verena Siewers and Thomas Andlid
    Citation: Microbial Cell Factories 2023 22:160
  45. Conjugate vaccines produced either by chemical or biologically conjugation have been demonstrated to be safe and efficacious in protection against several deadly bacterial diseases. However, conjugate vaccine ...

    Authors: Sherif Abouelhadid, Elizabeth R. Atkins, Emily J. Kay, Ian J. Passmore, Simon J. North, Burhan Lehri, Paul Hitchen, Eirik Bakke, Mohammed Rahman, Janine T. Bossé, Yanwen Li, Vanessa S. Terra, Paul R. Langford, Anne Dell, Brendan W. Wren and Jon Cuccui
    Citation: Microbial Cell Factories 2023 22:159
  46. During the production of L-arginine through high dissolved oxygen and nitrogen supply fermentation, the industrial workhorse Corynebacterium glutamicum is exposed to oxidative stress. This generates reactive oxyg...

    Authors: Ziqin Jiang, Jingyi Guan, Tingting Liu, Chunyu Shangguan, Meijuan Xu and Zhiming Rao
    Citation: Microbial Cell Factories 2023 22:158

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