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  1. Vibrio pathogens are causative agents of mid-culture outbreaks, and early mortality syndrome and secondary aetiology of most dreadful viral outbreaks in shrimp aquaculture. Among the pathogenic vibrios group, Vib...

    Authors: George Seghal Kiran, Anuj Nishanth Lipton, Sethu Priyadharshini, Kumar Anitha, Lucia Elizabeth Cruz Suárez, Mariadhas Valan Arasu, Ki Choon Choi, Joseph Selvin and Naif Abdullah Al-Dhabi
    Citation: Microbial Cell Factories 2014 13:114

    The Correction to this article has been published in Microbial Cell Factories 2021 20:21

  2. One-pot multi-step biocatalysis is advantageous over step-by-step synthesis as it reduces the number of process operation units, leading to significant process intensification. Whole-cell biocatalysis with met...

    Authors: Nora Weber, Marie Gorwa-Grauslund and Magnus Carlquist
    Citation: Microbial Cell Factories 2014 13:118
  3. Recombinant antibodies are highly successful in many different pathological conditions and currently enjoy overwhelming recognition of their potential. There are a wide variety of protein expression systems av...

    Authors: Ana Blanco-Toribio, Javier Lacadena, Natalia Nuñez-Prado, Ana Álvarez-Cienfuegos, Maider Villate, Marta Compte, Laura Sanz, Francisco J Blanco and Luis Álvarez-Vallina
    Citation: Microbial Cell Factories 2014 13:116
  4. Development of mucosal vaccines strongly relies on an efficient delivery system and, over the years, a variety of approaches based on phages, bacteria or synthetic nanoparticles have been proposed to display a...

    Authors: Ezio Ricca, Loredana Baccigalupi, Giuseppina Cangiano, Maurilio De Felice and Rachele Isticato
    Citation: Microbial Cell Factories 2014 13:115
  5. Ergot alkaloids are a group of highly bioactive molecules produced by a number of filamentous fungi. These compounds have been intensely studied for decades, mainly due to their deleterious effects in contamin...

    Authors: Curt AF Nielsen, Christophe Folly, Anaëlle Hatsch, Andrea Molt, Hartwig Schröder, Sarah E O’Connor and Michael Naesby
    Citation: Microbial Cell Factories 2014 13:95
  6. Itaconic acid, which has been declared to be one of the most promising and flexible building blocks, is currently used as monomer or co-monomer in the polymer industry, and produced commercially by Aspergillus te...

    Authors: Xuenian Huang, Xuefeng Lu, Yueming Li, Xia Li and Jian-Jun Li
    Citation: Microbial Cell Factories 2014 13:119
  7. A previously discovered mutant of Saccharomyces cerevisiae alcohol dehydrogenase 1 (Adh1p) was shown to enable a unique NADH-dependent reduction of 5-hydroxymethylfurfural (HMF), a well-known inhibitor of yeast f...

    Authors: Boaz Laadan, Valeria Wallace-Salinas, Åsa Janfalk Carlsson, João RM Almeida, Peter Rådström and Marie F Gorwa-Grauslund
    Citation: Microbial Cell Factories 2014 13:112
  8. Microalgae have been an emerging biofuel resource; however, the germplasm improvement has been slow due to the lack of molecular tools. Pyruvate dehydrogenase kinase (PDK) deactivates the pyruvate dehydrogenas...

    Authors: Yu-Han Ma, Xiang Wang, Ying-Fang Niu, Zhi-Kai Yang, Meng-Han Zhang, Zhong-Ming Wang, Wei-Dong Yang, Jie-Sheng Liu and Hong-Ye Li
    Citation: Microbial Cell Factories 2014 13:100
  9. Bioplastics, like polylactic acid (PLA), are renewable alternatives for petroleum-based plastics. Lactic acid, the monomer of PLA, has traditionally been produced biotechnologically with bacteria. Wi...

    Authors: Kari T Koivuranta, Marja Ilmén, Marilyn G Wiebe, Laura Ruohonen, Pirkko Suominen and Merja Penttilä
    Citation: Microbial Cell Factories 2014 13:107
  10. The autotransporter (AT) system can potentially be used in the secretion of saccharolytic enzymes for the production of lignocellulosic biofuels and chemicals using Escherichia coli. Although ATs share similar st...

    Authors: Iván Muñoz-Gutiérrez, Cessna Moss-Acosta, Berenice Trujillo-Martinez, Guillermo Gosset and Alfredo Martinez
    Citation: Microbial Cell Factories 2014 13:106
  11. It is generally believed that there are many natural sources of as yet unknown bioactive compounds with a high biotechnological potential. However, the common method based on the use of cell extracts in the pr...

    Authors: Agnieszka Felczykowska, Aleksandra Dydecka, Małgorzata Bohdanowicz, Tomasz Gąsior, Marek Soboň, Justyna Kobos, Sylwia Bloch, Bożena Nejman-Faleńczyk and Grzegorz Węgrzyn
    Citation: Microbial Cell Factories 2014 13:105
  12. Ebosin is a novel exopolysaccharide (EPS) produced by Streptomyces sp. 139 and evidenced to possess an anti-rheumatic arthritis activity in vivo. The Ebosin biosynthesis gene cluster (ste) consists of 27 ORFs and...

    Authors: Yang Zhang, Junjie Shan, Yonggang Bao, Liping Bai, Rong Jiang, Lianhong Guo, Chen Yao, Ren Zhang and Yuan Li
    Citation: Microbial Cell Factories 2014 13:103
  13. One of the major challenges of nanotechnology during the last decade has been the development of new procedures to synthesize nanoparticles. In this context, biosynthetic methods have taken hold since they are...

    Authors: Nicolás Alexis Órdenes-Aenishanslins, Luis Alberto Saona, Vicente María Durán-Toro, Juan Pablo Monrás, Denisse Margarita Bravo and José Manuel Pérez-Donoso
    Citation: Microbial Cell Factories 2014 13:90
  14. Vitamin B12 is a fascinating molecule which acts as a co-factor in the metabolism of many organisms, especially affecting DNA synthesis and regulation, fatty acid synthesis and energy production. The synthesis...

    Authors: Yousef Mohammed, Byong Lee, Zhen Kang and Guocheng Du
    Citation: Microbial Cell Factories 2014 13:102
  15. Purine nucleotides are essential metabolites for living organisms because they are involved in many important processes, such as nucleic acid synthesis, energy supply, and biosynthesis of several amino acids a...

    Authors: Ting Shi, Yongcheng Wang, Zhiwen Wang, Guanglu Wang, Dingyu Liu, Jing Fu, Tao Chen and Xueming Zhao
    Citation: Microbial Cell Factories 2014 13:101
  16. Butanol is an industrial commodity and also considered to be a more promising gasoline substitute compared to ethanol. Renewed attention has been paid to solvents (acetone, butanol and ethanol) production from...

    Authors: Zhiqiang Wen, Mianbin Wu, Yijun Lin, Lirong Yang, Jianping Lin and Peilin Cen
    Citation: Microbial Cell Factories 2014 13:92
  17. For the production of L-phenylalanine (L-Phe), two molecules of phosphoenolpyruvate (PEP) and one molecule erythrose-4-phosphate (E4P) are necessary. PEP stems from glycolysis whereas E4P is formed in the pent...

    Authors: Katrin Gottlieb, Christoph Albermann and Georg A Sprenger
    Citation: Microbial Cell Factories 2014 13:96
  18. The use of fossil carbon sources for fuels and petrochemicals has serious impacts on our environment and is unable to meet the demand in the future. A promising and sustainable alternative is to substitute fos...

    Authors: Anna Monika Boguta, Françoise Bringel, Jan Martinussen and Peter Ruhdal Jensen
    Citation: Microbial Cell Factories 2014 13:97
  19. Glucose repression is a global regulatory system in baker’s yeast. Maltose metabolism in baker’s yeast strains is negatively influenced by glucose, thereby affecting metabolite productivity (leavening ability ...

    Authors: Xue Lin, Cui-Ying Zhang, Xiao-Wen Bai, Hai-Yan Song and Dong-Guang Xiao
    Citation: Microbial Cell Factories 2014 13:93
  20. The release of antibiotics into aquatic environments has made the treatment of wastewater containing antibiotics a world-wide public health problem. The ability of microbial fuel cells (MFCs) to harvest electr...

    Authors: Wenguo Wu, Keaton Larson Lesnik, Shoutao Xu, Luguang Wang and Hong Liu
    Citation: Microbial Cell Factories 2014 13:91
  21. Pseudomnas putida is a natural producer of medium chain length polyhydroxyalkanoates (mcl-PHA), a polymeric precursor of bioplastics. A two-fold increase of mcl-PHA production via inactivation of the glucose deh...

    Authors: José Manuel Borrero-de Acuña, Agata Bielecka, Susanne Häussler, Max Schobert, Martina Jahn, Christoph Wittmann, Dieter Jahn and Ignacio Poblete-Castro
    Citation: Microbial Cell Factories 2014 13:88
  22. An ideal immobilized biocatalyst for the industrial-scale production of invert sugar should stably operate at elevated temperatures (60-70°C) and high sucrose concentrations (above 60%, w/v). Commercial invert...

    Authors: Duniesky Martínez, Carmen Menéndez, Félix M Echemendia, Enrique R Pérez, Luis E Trujillo, Alina Sobrino, Ricardo Ramírez, Yamira Quintero and Lázaro Hernández
    Citation: Microbial Cell Factories 2014 13:87
  23. Saccharomyces cerevisiae is the most relevant yeast species conducting the alcoholic fermentation that takes place during winemaking. Although the physiology of this model organism has been extensively studied, ...

    Authors: Felícitas Vázquez-Lima, Paulina Silva, Antonio Barreiro, Rubén Martínez-Moreno, Pilar Morales, Manuel Quirós, Ramón González, Joan Albiol and Pau Ferrer
    Citation: Microbial Cell Factories 2014 13:85
  24. Enantiomerically pure alcohols are important building blocks for production of chiral pharmaceuticals, flavors, agrochemicals and functional materials and appropriate whole-cell biocatalysts offer a highly ena...

    Authors: Peng-Xuan Du, Ping Wei, Wen-Yong Lou and Min-Hua Zong
    Citation: Microbial Cell Factories 2014 13:84
  25. Microbial lipids represent a valuable alternative feedstock for biodiesel production when oleaginous microbes are cultured with inexpensive substrates in processes exhibiting high yield and productivity. In th...

    Authors: Stefano Raimondi, Maddalena Rossi, Alan Leonardi, Michele Maria Bianchi, Teresa Rinaldi and Alberto Amaretti
    Citation: Microbial Cell Factories 2014 13:83
  26. From fundamental studies to industrial processes, synthesis of heterologous protein by micro-organisms is widely employed. The secretion of soluble heterologous proteins in the extracellular medium facilitates...

    Authors: Xavier Lecomte, Valérie Gagnaire, Valérie Briard-Bion, Julien Jardin, Sylvie Lortal, Annie Dary and Magali Genay
    Citation: Microbial Cell Factories 2014 13:82
  27. Autotransporter proteins represent a treasure trove for molecular engineers who modify Gram-negative bacteria for the export or secretion of foreign proteins across two membrane barriers. A particularly promis...

    Authors: Junjie Zhang, Leon De Masi, Beena John, Wenxin Chen and Dieter M Schifferli
    Citation: Microbial Cell Factories 2014 13:80
  28. Green microalgae represent a renewable natural source of vitamin E. Its most bioactive form is the naturally occurring RRR-α-tocopherol which is biosynthesized in photosynthetic organisms as a single stereoisomer...

    Authors: Ganapathy Sivakumar, Kwangkook Jeong and Jackson O Lay Jr
    Citation: Microbial Cell Factories 2014 13:79
  29. L-Lactic acid, one of the most important chiral molecules and organic acids, is produced via pyruvate from carbohydrates in diverse microorganisms catalyzed by an NAD+-dependent L-lactate dehydrogenase. Naturally...

    Authors: Dandan Niu, Kangming Tian, Bernard A Prior, Min Wang, Zhengxiang Wang, Fuping Lu and Suren Singh
    Citation: Microbial Cell Factories 2014 13:78
  30. Lactococcus lactis is widely used as a dairy starter and has been extensively studied. Based on the acquired knowledge on its physiology and metabolism, new applications have been envisaged and there is an incre...

    Authors: Ana B Campelo, Clara Roces, M Luz Mohedano, Paloma López, Ana Rodríguez and Beatriz Martínez
    Citation: Microbial Cell Factories 2014 13:77
  31. Lactobacillus reuteri converts glycerol to 3-hydroxypropionic acid (3HP) and 1,3-propanediol (1,3PDO) via 3-hydroxypropionaldehyde (3HPA) as an intermediate using enzymes encoded in its propanediol-utilization (

    Authors: Tarek Dishisha, Luciana P Pereyra, Sang-Hyun Pyo, Robert A Britton and Rajni Hatti-Kaul
    Citation: Microbial Cell Factories 2014 13:76
  32. Controlling harmful algae blooms (HABs) using microbial algicides is cheap, efficient and environmental-friendly. However, obtaining high yield of algicidal microbes to meet the need of field test is still a b...

    Authors: Guanjing Cai, Wei Zheng, Xujun Yang, Bangzhou Zhang and Tianling Zheng
    Citation: Microbial Cell Factories 2014 13:75
  33. To attain a sustainable bioeconomy, fuel, or valuable product, production must use biomass as substrate. Starch is one of the most abundant biomass resources and is present as waste or as a food and agroindust...

    Authors: Luis Manuel Rosales-Colunga and Agustino Martínez-Antonio
    Citation: Microbial Cell Factories 2014 13:74
  34. For filamentous fungi, the basic growth unit of hyphae usually makes it sensitive to shear stress which is generated from mechanical force and dynamic fluid in bioreactor, and it severely decreases microbial p...

    Authors: Menghao Cai, Ying Zhang, Wei Hu, Wei Shen, Zhenzhong Yu, Weiqiang Zhou, Tao Jiang, Xiangshan Zhou and Yuanxing Zhang
    Citation: Microbial Cell Factories 2014 13:73
  35. The use of cold-active enzymes has many advantages, including reduced energy consumption and easy inactivation. The ikaite columns of SW Greenland are permanently cold (4-6°C) and alkaline (above pH 10), and t...

    Authors: Jan Kjølhede Vester, Mikkel Andreas Glaring and Peter Stougaard
    Citation: Microbial Cell Factories 2014 13:72
  36. Kojic acid (5-Hydroxy-2-(hydroxymethyl)-4-pyrone) is one of the major secondary metabolites in Aspergillus oryzae. It is widely used in food, pharmaceuticals, and cosmetics. The production cost, however, is too h...

    Authors: Ryosuke Yamada, Toshihide Yoshie, Satoshi Wakai, Nanami Asai-Nakashima, Fumiyoshi Okazaki, Chiaki Ogino, Hiromoto Hisada, Hiroko Tsutsumi, Yoji Hata and Akihiko Kondo
    Citation: Microbial Cell Factories 2014 13:71
  37. 1,3-propanediol (PDO) is a substantially industrial metabolite used in the polymer industry. Although several natural PDO production hosts exist, e.g. Klebsiella sp., Citrobacter sp. and Clostridium sp., the PDO ...

    Authors: Veerle ET Maervoet, Sofie L De Maeseneire, Fatma G Avci, Joeri Beauprez, Wim K Soetaert and Marjan De Mey
    Citation: Microbial Cell Factories 2014 13:70
  38. Inclusion bodies (IBs) were generally considered to be inactive protein deposits and did not hold any attractive values in biotechnological applications. Recently, some IBs of recombinant proteins were confirm...

    Authors: Govindan Raghunathan, Ganapathiraman Munussami, Hyojin Moon, Hyun-jong Paik, Seong Soo A An, Yong-Sung Kim, Sebyung Kang and Sun-Gu Lee
    Citation: Microbial Cell Factories 2014 13:989
  39. Current soil management strategies are mainly dependent on inorganic chemical-based fertilizers, which caused a serious threat to human health and environment. The exploitation of beneficial microbes as a biof...

    Authors: Deepak Bhardwaj, Mohammad Wahid Ansari, Ranjan Kumar Sahoo and Narendra Tuteja
    Citation: Microbial Cell Factories 2014 13:66
  40. 3-hydroxypropionic acid (3HP) is an important chemical precursor for the production of bioplastics. Microbial production of 3HP from glycerol has previously been developed through the optimization of culture c...

    Authors: Kento Tokuyama, Satoshi Ohno, Katsunori Yoshikawa, Takashi Hirasawa, Shotaro Tanaka, Chikara Furusawa and Hiroshi Shimizu
    Citation: Microbial Cell Factories 2014 13:64
  41. Bacterial cellulose (BC) is a polymeric nanostructured fibrillar network produced by certain microorganisms, principally Gluconacetobacter xylinus. BC has a great potential of application in many fields. Lignocel...

    Authors: Shuo Zhang, Sandra Winestrand, Xiang Guo, Lin Chen, Feng Hong and Leif J Jönsson
    Citation: Microbial Cell Factories 2014 13:62
  42. Thermus thermophilus, an extremely thermophilic bacterium, has been widely recognized as a model organism for studying how microbes can survive and adapt under high temperature environment. However, the thermoto...

    Authors: Na-Rae Lee, Meiyappan Lakshmanan, Shilpi Aggarwal, Ji-Won Song, Iftekhar A Karimi, Dong-Yup Lee and Jin-Byung Park
    Citation: Microbial Cell Factories 2014 13:61

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