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  1. Energy from remote methane reserves is transformative; however, unintended release of this potent greenhouse gas makes it imperative to convert methane efficiently into more readily transported biofuels. No pu...

    Authors: Valerie W. C. Soo, Michael J. McAnulty, Arti Tripathi, Fayin Zhu, Limin Zhang, Emmanuel Hatzakis, Philip B. Smith, Saumya Agrawal, Hadi Nazem-Bokaee, Saratram Gopalakrishnan, Howard M. Salis, James G. Ferry, Costas D. Maranas, Andrew D. Patterson and Thomas K. Wood
    Citation: Microbial Cell Factories 2016 15:11
  2. Catalase (EC 1.11.1.6) is one of the important industrial enzyme employed in diagnostic and analytical methods in the form of biomarkers and biosensors in addition to their enormous applications in textile, pa...

    Authors: Baljinder Singh Kauldhar and Balwinder Singh Sooch
    Citation: Microbial Cell Factories 2016 15:7
  3. Sustainable alternatives for the production of fuels and chemicals are needed to reduce our dependency on fossil resources and to avoid the negative impact of their excessive use on the global climate. Lignoce...

    Authors: Stefan Marcus Gaida, Andrea Liedtke, Andreas Heinz Wilhelm Jentges, Benedikt Engels and Stefan Jennewein
    Citation: Microbial Cell Factories 2016 15:6
  4. Enantiopure (S)-1-(4-methoxyphenyl) ethanol {(S)-MOPE} can be employed as an important synthon for the synthesis of cycloalkyl [b] indoles with the treatment function for g...

    Authors: Ping Wei, Jing Liang, Jing Cheng, Min-Hua Zong and Wen-Yong Lou
    Citation: Microbial Cell Factories 2016 15:5
  5. With the increasing global crude oil crisis and resulting environmental concerns, the production of biofuels from renewable resources has become increasingly important. One of the major challenges faced during...

    Authors: Furong Tan, Bo Wu, Lichun Dai, Han Qin, Zongxia Shui, Jingli Wang, Qili Zhu, Guoquan Hu and Mingxiong He
    Citation: Microbial Cell Factories 2016 15:4
  6. Polylactic acid (PLA) is one important chemical building block that is well known as a biodegradable and a biocompatible plastic. The traditional lactate fermentation pr...

    Authors: Nilnate Assavasirijinda, Deyong Ge, Bo Yu, Yanfen Xue and Yanhe Ma
    Citation: Microbial Cell Factories 2016 15:3
  7. Isepamicin is a weakly toxic but highly active aminoglycoside antibiotic derivative of gentamicin B. Gentamicin B is a naturally occurring minor component isolated from Micromonospora echinospora. 2ʹ-NH2-containi...

    Authors: Xianpu Ni, Zhenpeng Sun, Yawen Gu, Hao Cui and Huanzhang Xia
    Citation: Microbial Cell Factories 2016 15:1
  8. Tannase is an enzyme that catalyses the breakdown of ester bonds in gallotannins such as tannic acid. In recent years, the interest on bacterial tannases has increased b...

    Authors: Pedro Aguilar-Zárate, Mario A. Cruz, Julio Montañez, Raúl Rodríguez-Herrera, Jorge E. Wong-Paz, Ruth E. Belmares and Cristóbal N. Aguilar
    Citation: Microbial Cell Factories 2015 14:209
  9. Lactococcus lactis has been safely consumed in fermented foods for millennia. This Gram-positive bacterium has now become of industrial importance as an expression host for the overpro...

    Authors: Daniel M. Linares, Patricia Alvarez-Sieiro, Beatriz del Rio, Victor Ladero, Begoña Redruello, Mª Cruz Martin, Maria Fernandez and Miguel A. Alvarez
    Citation: Microbial Cell Factories 2015 14:208
  10. In most bacteria, various jumping genetic elements including insertion sequences elements (IS elements) cause a variety of genetic rearrangements resulting in harmful effects such as genome and recombinant pla...

    Authors: Jae Woong Choi, Sung Sun Yim, Min Jeong Kim and Ki Jun Jeong
    Citation: Microbial Cell Factories 2015 14:207
  11. Genome-scale models (GSMs) are widely used to predict cyanobacterial phenotypes in photobioreactors (PBRs). However, stoichiometric GSMs mainly focus on fluxome that result in maximal yields. Cyanobacterial me...

    Authors: Lian He, Stephen G. Wu, Ni Wan, Adrienne C. Reding and Yinjie J. Tang
    Citation: Microbial Cell Factories 2015 14:206
  12. Although some microorganisms can convert glycerol into valuable products such as polyunsaturated fatty acids, the yields are relative low due primarily to an inefficient assimilation of glycerol. Mortierella alpi...

    Authors: Guangfei Hao, Haiqin Chen, Zhennan Gu, Hao Zhang, Wei Chen and Yong Q. Chen
    Citation: Microbial Cell Factories 2015 14:205
  13. The l-arabinose isomerase is an intracellular enzyme which converts l-arabinose into l-ribulose in living systems and d-galactose into d-tagatose in industrial processes and at industrial scales. d-tagatose is a ...

    Authors: Moez Rhimi, Luis G. Bermudez-Humaran, Yuan Huang, Samira Boudebbouze, Nadia Gaci, Alexandrine Garnier, Jean-Jacques Gratadoux, Héla Mkaouar, Philippe Langella and Emmanuelle Maguin
    Citation: Microbial Cell Factories 2015 14:204
  14. Methylxanthines are natural and synthetic compounds found in many foods, drinks, pharmaceuticals, and cosmetics. Aside from caffeine, production of many methylxanthines is currently performed by chemical synth...

    Authors: Khalid H. R. Algharrawi, Ryan M. Summers, Sridhar Gopishetty and Mani Subramanian
    Citation: Microbial Cell Factories 2015 14:203
  15. Hypertension is considered the most serious risk factor for cardiovascular disease. Angiotensin-converting enzyme inhibitory peptides (ACEIPs), which are made from tuna frame protein (TFP) and yellow fin sole ...

    Authors: Guilian Yang, Yanlong Jiang, Wentao Yang, Fang Du, Yunbao Yao, Chunwei Shi and Chunfeng Wang
    Citation: Microbial Cell Factories 2015 14:202
  16. Heterologous expression systems based on promoters inducible with isopropyl-β-D-1-thiogalactopyranoside (IPTG), e.g., Escherichia coli BL21(DE3) and cognate LacIQ/P ...

    Authors: Pavel Dvorak, Lukas Chrast, Pablo I. Nikel, Radek Fedr, Karel Soucek, Miroslava Sedlackova, Radka Chaloupkova, Víctor de Lorenzo, Zbynek Prokop and Jiri Damborsky
    Citation: Microbial Cell Factories 2015 14:201
  17. Several studies in animal models demonstrated that obligate and facultative anaerobic bacteria of the genera Bifidobacterium, Salmonella, or Clostridium specifically colonize solid tumors. Consequently, these and...

    Authors: Annika Osswald, Zhongke Sun, Verena Grimm, Grace Ampem, Karin Riegel, Astrid M. Westendorf, Wolfgang Sommergruber, Kerstin Otte, Peter Dürre and Christian U. Riedel
    Citation: Microbial Cell Factories 2015 14:199
  18. Adenosine-5′-triphosphate (ATP) is consumed as a biological energy source by many intracellular reactions. Thus, the intracellular ATP supply is required to maintain cellular ho...

    Authors: Kiyotaka Y. Hara and Akihiko Kondo
    Citation: Microbial Cell Factories 2015 14:198
  19. The lactic acid bacterium Lactobacillus rhamnosus GG is the most studied probiotic bacterium with proven health benefits upon oral intake, including the alleviation of diarrhea. The mission of the Yoba for Life f...

    Authors: Remco Kort, Nieke Westerik, L. Mariela Serrano, François P. Douillard, Willi Gottstein, Ivan M. Mukisa, Coosje J. Tuijn, Lisa Basten, Bert Hafkamp, Wilco C. Meijer, Bas Teusink, Willem M. de Vos, Gregor Reid and Wilbert Sybesma
    Citation: Microbial Cell Factories 2015 14:195
  20. Promoters are indispensable elements of a standardized parts collection for synthetic biology. Regulated promoters of a wide variety of well-defined induction ratios and expression strengths are highly interes...

    Authors: Brigitte Gasser, Matthias G. Steiger and Diethard Mattanovich
    Citation: Microbial Cell Factories 2015 14:196
  21. As a metabolic engineering tool, an adaptive laboratory evolution (ALE) experiment was performed to increase the specific growth rate (µ) in an Escherichia coli strain lacking PTS, originally engineered to increa...

    Authors: César Aguilar, Noemí Flores, Fernando Riveros-McKay, Diana Sahonero-Canavesi, Susy Beatriz Carmona, Otto Geiger, Adelfo Escalante and Francisco Bolívar
    Citation: Microbial Cell Factories 2015 14:194
  22. High-throughput screening methods assume that the output measured is representative of changes in metabolic flux toward the desired product and is not affected by secondary phenotypes. However, metabolic engin...

    Authors: Mareike Bongers, Panagiotis K. Chrysanthopoulos, James B. Y. H. Behrendorff, Mark P. Hodson, Claudia E. Vickers and Lars K. Nielsen
    Citation: Microbial Cell Factories 2015 14:193
  23. PII signal processor proteins are wide spread in prokaryotes and plants where they control a multitude of anabolic reactions. Efficient overproduction of metabolites requires relaxing the tight cellular control c...

    Authors: Björn Watzer, Alicia Engelbrecht, Waldemar Hauf, Mark Stahl, Iris Maldener and Karl Forchhammer
    Citation: Microbial Cell Factories 2015 14:192
  24. Quorum sensing (QS) networks are more commonly known as acyl homoserine lactone (HSL) networks. Recently, p-coumaroyl-HSL has been found in a photosynthetic bacterium. p-coumaroyl-HSL is derived from a lignin mon...

    Authors: Sun-Young Kang, Jae Kyoung Lee, Jae-Hyuk Jang, Bang Yeon Hwang and Young-Soo Hong
    Citation: Microbial Cell Factories 2015 14:191
  25. Laboratory scale recombinant protein production and purification techniques are often complicated, involving multiple chromatography steps and specialized equipment and reagents. Here it was demonstrated that ...

    Authors: Iain D. Hay, Jinping Du, Patricia Rubio Reyes and Bernd H. A. Rehm
    Citation: Microbial Cell Factories 2015 14:190
  26. Mucosal delivery of therapeutic proteins using genetically modified strains of lactic acid bacteria (gmLAB) is being investigated as a new therapeutic strategy.

    Authors: Suguru Shigemori, Takafumi Watanabe, Kai Kudoh, Masaki Ihara, Shireen Nigar, Yoshinari Yamamoto, Yoshihito Suda, Takashi Sato, Haruki Kitazawa and Takeshi Shimosato
    Citation: Microbial Cell Factories 2015 14:189
  27. Methane-utilizing bacteria (methanotrophs) are capable of growth on methane and are attractive systems for bio-catalysis. However, the application of natural methanotrophic strains to large-scale production of...

    Authors: Andrea de la Torre, Aisha Metivier, Frances Chu, Lieve M. L. Laurens, David A. C. Beck, Philip T. Pienkos, Mary E. Lidstrom and Marina G. Kalyuzhnaya
    Citation: Microbial Cell Factories 2015 14:188
  28. Phasin (PhaP), a kind of polyhydroxyalkanoate (PHA) granule-associated proteins, has a role in controlling the properties of PHA granules surface, and is thought to have influence on PHA biosynthesis in PHA-pr...

    Authors: Yui Kawashima, Izumi Orita, Satoshi Nakamura and Toshiaki Fukui
    Citation: Microbial Cell Factories 2015 14:187
  29. Propionibacterium freudenreichii is a food grade bacterium that has gained attention as a producer of appreciable amounts of cobalamin, a cobamide with activity of vitamin B12. Product...

    Authors: Paulina Deptula, Petri Kylli, Bhawani Chamlagain, Liisa Holm, Risto Kostiainen, Vieno Piironen, Kirsi Savijoki and Pekka Varmanen
    Citation: Microbial Cell Factories 2015 14:186
  30. Poly(3-hydroxybutyrate) (PHB), have been considered to be good candidates for completely biodegradable polymers due to their similar mechanical properties to petroleum-d...

    Authors: Zhenquan Lin, Yan Zhang, Qianqian Yuan, Qiaojie Liu, Yifan Li, Zhiwen Wang, Hongwu Ma, Tao Chen and Xueming Zhao
    Citation: Microbial Cell Factories 2015 14:185
  31. Authors: Christophe Michon, Katarzyna Kuczkowska, Philippe Langella, Vincent G. H. Eijsink, Geir Mathiesen and Jean-Marc Chatel
    Citation: Microbial Cell Factories 2015 14:184

    The original article was published in Microbial Cell Factories 2015 14:95

  32. Methane is a feedstock of interest for the future, both from natural gas and from renewable biogas sources. Methanotrophic bacteria have the potential to enable commercial methane bioconversion to value-added ...

    Authors: Alexey Gilman, Lieve M. Laurens, Aaron W. Puri, Frances Chu, Philip T. Pienkos and Mary E. Lidstrom
    Citation: Microbial Cell Factories 2015 14:182
  33. In vivo imaging of orally administered lactic acid bacteria (LAB) and commensal bacteria in mice is shown to provide information on the spatial and temporal distribution of bacteria in the gastrointestinal tra...

    Authors: Aleš Berlec, Janja Završnik, Miha Butinar, Boris Turk and Borut Štrukelj
    Citation: Microbial Cell Factories 2015 14:181
  34. Whole cell biocatalysts and isolated enzymes are considered as state of the art in biocatalytic preparations for industrial applications. Whole cells as biocatalysts are disadvantageous if substrate or product...

    Authors: Ilka Sührer, Timo Langemann, Werner Lubitz, Dirk Weuster-Botz and Kathrin Castiglione
    Citation: Microbial Cell Factories 2015 14:180
  35. Secretion of cytoplasmic expressed proteins into growth media has significant advantages. Due to the lack of an outer membrane, Bacillus subtilis is considered as a desirable ‘cell factory’ for the secretion of r...

    Authors: Guangqiang Wang, Yongjun Xia, Zhennan Gu, Hao Zhang, Yong Q. Chen, Haiqin Chen, Lianzhong Ai and Wei Chen
    Citation: Microbial Cell Factories 2015 14:179
  36. Some types of flavonoid intermediates seemed to be restricted to plants. Naringenin is a typical plant metabolite, that has never been reported to be produced in prokari...

    Authors: Rubén Álvarez-Álvarez, Alma Botas, Silvia M. Albillos, Angel Rumbero, Juan F. Martín and Paloma Liras
    Citation: Microbial Cell Factories 2015 14:178
  37. The use of astaxanthin in different industries such as the chemical, pharmaceutical, food, animal feed and cosmetic has been receiving increasing attention in recent years. Natural supplies of the pigment incl...

    Authors: Isabel Rodríguez Amado and José Antonio Vázquez
    Citation: Microbial Cell Factories 2015 14:177
  38. Thymic stromal lymphopoietin (TSLP) is a cytokine known to mature dendritics cells, lower pro-inflammatory IL-12 secretion, induce differentiation of anti-inflammatory FoxP3+ regulatory T cells (Treg). Moreove...

    Authors: Camille Aubry, Christophe Michon, Florian Chain, Yolande Chvatchenko, Laurence Goffin, Simone C. Zimmerli, Sylvia Leguin, Philippe Langella, Luis Bermudez-Humaran and Jean-Marc Chatel
    Citation: Microbial Cell Factories 2015 14:176

    The Erratum to this article has been published in Microbial Cell Factories 2016 15:188

  39. An increasing number of proteins are being shown to assemble into amyloid structures that lead to pathological states. Among them, mammalian prions outstand due to their ability to transmit the pathogenic conf...

    Authors: Bruno Macedo, Ricardo Sant’Anna, Susanna Navarro, Yraima Cordeiro and Salvador Ventura
    Citation: Microbial Cell Factories 2015 14:174
  40. Streptomycetes attract a lot of attention in metabolic engineering and synthetic biology because of their well-known ability to produce secondary metabolites. However, the available constitutive promoters are ...

    Authors: Shanshan Li, Junyang Wang, Xiao Li, Shouliang Yin, Weishan Wang and Keqian Yang
    Citation: Microbial Cell Factories 2015 14:172
  41. 2,3-Butanediol is an important bulk chemical with a wide range of applications. In bacteria, this metabolite is synthesised from pyruvate via a three-step pathway involving α-acetolactate synthase, α-acetolact...

    Authors: Dušica Radoš, Ana Lúcia Carvalho, Stefan Wieschalka, Ana Rute Neves, Bastian Blombach, Bernhard J. Eikmanns and Helena Santos
    Citation: Microbial Cell Factories 2015 14:171
  42. Rhodosporidium and Rhodotorula are two genera of oleaginous red yeast with great potential for industrial biotechnology. To date, there is no effective method for inducible expression ...

    Authors: Yanbin Liu, Chong Mei John Koh, Si Te Ngoh and Lianghui Ji
    Citation: Microbial Cell Factories 2015 14:170

    The Erratum to this article has been published in Microbial Cell Factories 2017 16:107

  43. Chemokines are attractive candidates for vaccine adjuvants due to their ability to recruit the immune cells. Lactic acid bacteria (LAB)-based delivery vehicles have potential to be used as a cheap and safe opt...

    Authors: Katarzyna Kuczkowska, Geir Mathiesen, Vincent G. H. Eijsink and Inger Øynebråten
    Citation: Microbial Cell Factories 2015 14:169
  44. There is an increasing interest toward the use of legumes in food industry, mainly due to the quality of their protein fraction. Many legumes are cultivated and consumed around the world, but few data is avail...

    Authors: Carlo Giuseppe Rizzello, Blanca Hernández-Ledesma, Samuel Fernández-Tomé, José Antonio Curiel, Daniela Pinto, Barbara Marzani, Rossana Coda and Marco Gobbetti
    Citation: Microbial Cell Factories 2015 14:168

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