Table 3 Combined action of antibiotics and the extracted pigment
Antibiotics (µg) | Inhibition zone diameters (mm) | ||||
|---|---|---|---|---|---|
Single drug | Drug interaction (calculated) | Drug interaction (observed) | synergistic/antagonistic index | Drug interaction interpretation | |
Pigment only | 21 | ||||
Ciprofloxacin (CIP, 5) | 14 | (14 + 21) 35 | 39 | 1.11 | Synergistic effect |
Levofloxacin (LEV, 5) | 30 | 51 | 40 | 0.78 | Antagonistic effect |
Ceftriaxone (CRO, 30) | 0.0 | 21 | 8 | 0.38 | Antagonistic effect |
Amoxicillin (AX, 25 IU) | 0.0 | 21 | 12 | 0.57 | Antagonistic effect |
Cefuroxime (CXM, 30) | 0.0 | 21 | 25 | 1.19 | Synergistic effect |
Gentamicin (CN, 10) | 18 | 39 | 28 | 0.72 | Antagonistic effect |
Cefadroxil (CFR, 30) | 18 | 39 | 18 | 0.46 | Antagonistic effect |
Amoxicillin-Clavulinic Acid (AMC, 30) | 15 | 36 | 18 | 0.50 | Antagonistic effect |
Cefotaxime (CTX, 30) | 7 | 28 | 14 | 0.50 | Antagonistic effect |