Anti-inflammatory potential of Penicillium brefeldianum endophytic fungus supported with phytochemical profiling

Saleh, Asmaa; Negm, Walaa A.; El-Masry, Thanaa A.; Eliwa, Duaa; Alotaibi, Badriyah; Alosaimi, Manal E.; Alotaibi, Khalid Nijr; Magdeldin, Sameh; Mahgoub, Sebaey; Elekhnawy, Engy

doi:10.1186/s12934-023-02091-5

Table 2 List of tentatively identified metabolites in P. brefeldianum extract analyzed by LC–ESI–MS/MS

From: Anti-inflammatory potential of Penicillium brefeldianum endophytic fungus supported with phytochemical profiling

No	Rt (min)	Precursor m/z	Error ppm	Name	Formula	Adduct ion	MS/MS spectrum	Ontology
1	0.97	191.0218	0.5	Citric acid	C₆H₈O₇	[M−H]⁻	173.0090, 129.0181, 87.0088, 57.0347	Tricarboxylic acids and derivatives
2	1.03	133.0131	0.4	Malic acid	C₄H₆O₅	[M−H]⁻	115.0031, 89.0239, 71.0136, 59.0130	Beta hydroxy acids and derivatives
3	1.07	131.1291	− 0.6	Agmatine	C₅H₁₄N₄	[M+H]⁺	114.1020, 72.0806, 60.0554	Guanidines
4	1.09	189.1604	0.5	Laminine	C₉H₂₀N₂O₂	[M+H]⁺	130.0848, 84.0809, 60.0808	l-Alpha-amino acids
5	1.14	146.0447	0	l-Glutamic acid	C₅H₉NO₄	[M−H]⁻	128.0343, 102.0556	Glutamic acid and derivatives
6	1.16	195.0518	− 0.2	Gluconic acid	C₆H₁₂O₇	[M−H]⁻	176.9354, 87.0083, 75.0087, 59.0143	Medium-chain hydroxy acids and derivatives
7	1.18	104.1068	− 6.1	Choline	C₅H₁₄NO	[M]⁺	60.0800, 58.0645	Cholines
8	1.25	146.1171	− 0.4	l-beta-Homoisoleucine	C₇H₁₅NO₂	[M+H]⁺	87.0420, 60.0792, 58.0646	Beta amino acids and derivatives
9	1.29	130.0514	0.8	Leucine	C₆H₁₃NO₂	[M−H]⁻	84.0765, 61.9892	Leucine and derivatives
10	1.32	243.0613	− 0.7	Uridine	C₉H₁₂N₂O₆	[M−H]⁻	200.0560, 153.0300, 111.0192	Pyrimidine nucleosides
11	1.34	163.0612	− 0.5	l-(+)-Rhamnose	C₆H₁₂O₅	[M−H]⁻	101.0240, 85.0301, 71.0130, 59.0141	Hexoses
12	1.34	341.1043	0.1	Sucrose	C₁₂H₂₂O₁₁	[M−H]⁻	179.0570, 89.0247, 59.0143	O-glycosyl compounds
13	1.35	118.0863	− 0.9	Glycine–betaine	C₅H₁₁NO₂	[M+H]⁺	59.0731, 58.0654	Alpha amino acids
14	1.38	137.0431	0	Hypoxanthine	C₅H₄N₄O	[M+H]⁺	110.0356, 94.0406	Hypoxanthines
15	1.39	135.0324	− 0.7	Hypoxanthine	C₅H₄N₄O	[M−H]⁻	92.0251, 65.0136	Hypoxanthines
16	1.39	151.0254	0.4	Xylitol	C₅H₁₂O₅	[M−H]⁻	101.0242, 89.0239, 71.0139, 59.0139	Sugar alcohols
17	1.47	113.0303	− 0.5	Uracil	C₄H₄N₂O₂	[M+H]⁺	96.0086, 70.0285, 68.0122	Pyrimidones
18	1.62	124.0383	− 0.3	Nicotinic acid	C₆H₅NO₂	[M+H]⁺	106.0291, 80.0482, 78.0331	Pyridine carboxylic acids
19	1.74	130.0495	− 1.1	l-5-Oxoproline	C₅H₇NO₃	[M+H]⁺	84.0437, 56.0493	Alpha amino acids and derivatives
20	1.94	162.1119	0.2	Carnitine	C₇H₁₅NO₃	[M+H]⁺	103.0383, 102.0905, 60.0805	Carnitines
21	2.08	164.0723	− 0.9	Phenylalanine	C₉H₁₁NO₂	[M−H]⁻	147.0453, 103.0554, 72.0091	Phenylalanine and derivatives
22	3.63	298.0935	0.6	5′-Methylthioadenosine	C₁₁H₁₅N₅O₃S	[M+H]⁺	136.0611, 119.0346, 61.0104	5′-Deoxy-5′-thionucleosides
23	6.35	211.1442	− 0.9	3-(2-Methylpropyl)-2,3,6,7,8,8a-hexa hydro pyrrolo[1,2-a] pyrazine-1,4-dione	C₁₁H₁₈N₂O₂	[M+H]⁺	183.1483, 114.0921, 98.0587, 70.0650	Alpha amino acids derivatives
24	6.98	208.0959	− 0.8	N-Acetyl phenylalanine	C₁₁H₁₃NO₃	[M+H]⁺	166.0853, 162.0899, 120.0800, 103.0534	Phenylalanine and derivatives
25	7.02	197.1163	− 0.3	6-Hydroxy-4,4,7a-tri methyl-5,6,7,7a-tetrahydro benzofuran-2(4H)-one	C₁₁H₁₆O₃	[M+H]⁺	179.1062, 153.0676, 95.0850, 55.0524	Benzofurans
26	18.05	277.2159	0.1	Linolenic acid	C₁₈H₃₀O₂	[M−H]⁻	208.9232, 102.9573, 71.0152	Lineolic acids and derivatives
27	20.49	279.2324	− 0.3	Linoleic acid	C₁₈H₃₂O₂	[M−H]⁻	261.2235, 59.0148	Lineolic acids and derivatives

Back to article page

ISSN: 1475-2859

Contact us

Submission enquiries: journalsubmissions@springernature.com

Microbial Cell Factories

Contact us