Fig. 4

Paw sections stained with H&E: A normal control group revealing normal skin consisting of the epidermis of the average thickness (blue arrow) lined with thick keratin (red arrow) and underlying normal dermis (black arrow) (×100). B Positive control group revealing skin ulceration filled with a mixture of acute and chronic inflammatory cells (blue arrows) mixed with necrotic debris (red arrow) (×100). C Standard drug group revealed no inflammation, and the epidermis was thickened and covered with excessive keratosis (red arrow) with underlying marked collagenosis (black arrows) (×100). D Endophytic fungi group (100 mg/kg) revealing moderate dermal inflammation (red arrows), the epidermis was thickened and covered with mild keratosis (blue arrow) with underlying mild collagenosis (black arrow) (×100). E Endophytic fungi group (200 mg/kg) revealed few inflammatory cells (blue arrow), and the epidermis was thickened with keratosis (red arrow) as well as underlying moderate collagenosis (black arrow) (×100)