From: Advances in the optimization of central carbon metabolism in metabolic engineering
Host | Manipulation | CCM involved | Products | References |
---|---|---|---|---|
S. cerevisiae | Introduction of PHK pathway | Glycolysis and PPP | Farnesene | [23] |
S. cerevisiae | Introduction of PHK pathway | Glycolysis and PPP | Polyhydroxybutyrate | [25] |
S. cerevisiae | Introduction of PHK pathway | Glycolysis and PPP | p-Hydroxycinnamic acid | [30] |
S. cerevisiae | Introduction of PHK pathway and A-ALD | Glycolysis and PPP | β-Amyrin | [38] |
S. cerevisiae | Introduction of PHK pathway, overexpression of ADH2, ALD6 and acsSEL641P | Glycolysis and PPP | Fatty acid ethyl esters | [29] |
S. cerevisiae | Introduction of PHK pathway, multi-copy integration of Tal1 and Tkl1 | Glycolysis and PPP | Protopanaxadiol | [33] |
S. cerevisiae | Introduction of PK pathway | Glycolysis and PPP | Tyrosol and salidroside | [31] |
S. cerevisiae | Overexpression of a modified PDH pathway | Glycolysis | Acetyl-CoA | [36] |
S. cerevisiae | PDC1 deletion | Glycolysis | Pyruvate and lactate | [39] |
S. cerevisiae | PDC1 deletion | Glycolysis | 2,3-Butanediol | [40] |
S. cerevisiae | Deletion of HXK2 and GLK1, tTA-controlled expression of HXK1 | Glycolysis | Gluconate | [41] |
S. cerevisiae | Introduction of PHK pathway, downregulation of phosphoglucose isomerase, and overexpression Acc1 and Mcr | PPP | 3-Hydroxypropionic acid | [34] |
S. cerevisiae | Repression of Ric1 and overexpression of Rki1 | PPP | Shikimic acid, muconic acid and protocatechuic acid | [46] |
S. cerevisiae | Introduction of ACL from A. nidulans | TCA cycle | Mevalonate | [35] |
S. cerevisiae | Knockout of 15 genes of CCM | Glycolysis, PPP and TCA cycle | Triacetic acid lactone | [43] |
P. pastoris | Overexpression of Zwf, Pgi and Pfk1 | Glycolysis | Inositol | [42] |
P. pastoris | Control CCM by a synthetic constitutive transcriptional signal amplification device | Glycolysis | Monacolin J | [44] |
P. pastoris | Introduction of PHK pathway and the ACL from M. musculus | Glycolysis and TCA cycle | Free fatty acids and fatty alcohol | [28] |
Y. lipolytica | Introduction of PHK pathway and PFK deletion | Glycolysis | Lipid | [26] |
C. synechocystis | Expression of extra copies of PEPC | TCA cycle | Ethylene | [47] |
C. synechocystis | Expression of extra copies of PEPC and elevated culture temperature | Glycolysis and TCA cycle | Succinate | [48] |