Fig. 2
From: Advances in the optimization of central carbon metabolism in metabolic engineering
The schematic diagram of the CCM with modulated enzymes in E. coli. The black line represented glycolysis and pentose phosphate pathway, and the green line represented the tricarboxylic acid cycle. The red line represented the glucose PTS system and the blue line represented the pathway catalyzed by modulated enzymes. The orange dot represented the products in CCM, while the purple dot represented the products in glucose PTS system. G6P, Glucose 6-phosphate; F6P, Fructose-6-phosphate; F1,6P, Fructose-1,6-bisphosphate; GAP, Glyceraldehyde 3-phosphate; DHAP, Dihydroxyacetone phosphate; 13DPG, 3-Phospho-D-glyceroyl phosphate; 3PG, 3-Phosphoglycerate; 2PG, 2-Phosphoglycerate; PEP, Phosphoenolpyruvate; 6PG15L, 6-Phospho D-glucono-1,5-lactone; X5P, Xylulose 5-phophate; Ru5P, Ribulose 5-phophate; R5P, Ribose 5-phosphate; E4P, Erythrose 4-phosphate; S7P, Sedoheptulose 7-phophate; EI, Phosphotransferases enzyme I; Hpr, Histidine phosphate carrier protein; EIIAB, Phosphotransferases enzyme II A and B; EIIC, Phosphotransferases enzyme II C; PGI, Glucose-6-phosphate isomerase; ZWF, Glucose-6-phosphate dehydrogenase; PYK, Pyruvate kinase; PEPC, Phosphoenolpyruvate carboxylase; TPIA, Triosephosphate isomerase; FBAA, Fructose-bisphosphate aldolase; CS, Citrate synthase; LDHA, Lactate dehydrogenase; POXB, Pyruvate oxidase