Fig. 1
From: Advances in the optimization of central carbon metabolism in metabolic engineering
The optimization of CCM by introduction of heterologous pathways to improve the carbon flux in S. cerevisiae. The black line represented glycolysis and pentose phosphate pathway, and the green line represented the tricarboxylic acid cycle. The red, blue and brown lines represented the implemented PHK, PDH and ACL pathways. The orange dot represented the products in CCM, while the purple dot represented ACP. G6P, Glucose 6-phosphate; F6P, Fructose-6-phosphate; F1,6P, Fructose-1,6-bisphosphate; GAP, Glyceraldehyde 3-phosphate; DHAP, Dihydroxyacetone phosphate; BPG, 1,3-Bisphosphoglycerate; 3PG, 3-Phosphoglycerate; 2PG, 2-Phosphoglycerate; PEP, Phosphoenolpyruvate; 6PG, 6-Phosphogluconate; 6PGL, 6-Phosphate glucono-1,5-lactone; X5P, Xylulose 5-phophate; Ru5P, Ribulose 5-phophate; R5P, Ribose 5-phosphate; E4P, Erythrose 4-phosphate; S7P, Sedoheptulose 7-phophate; ACP, Acetyl-phosphate; Acetyl-CoA, Acetyl coenzyme A; PK, Phosphoketolase; PTA, Phosphotransacetylase; PDH, Pyruvate dehydrogenase; ACL, ATP: citrate lyase