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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)

Fig. 1

Metabolic pathway for poly(3-hydroxybutyrate) production through acetyl-CoA in E. coli cells. PanB, ketopantoate hydroxymethyltransferase; PanC, pantothenate synthetase; PanD, L-aspartate-α-decarboxylase; PanE, ketopantoate reductase; CoaA, pantothenate kinase; CoaB, 4'-phosphopantothenoylcysteine synthetase; CoaC, 4'-phosphopantothenoylcysteine decarboxylase; CoaD, phosphopantetheine adenylyltransferase; CoaE, dephospho-CoA kinase from E. coli. Exogenous genes encoding the enzymes indicated in bold letters were introduced into E. coli cells. P. putida CoaA, the bacterial type III pantothenate kinase from P. putida; M. aeruginosa PhaA, β-ketothiolase; PhaB, acetoacetyl-CoA reductase; PhaEC, polyhydroxyalkanoate synthase from M. aeruginosa

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